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Cannabis, Tobacco, and Vaping Final Set QUESTIONS AND CORRECT DETAILED ANSWERS {RATIONALES & IMAGES INCLUDED} |ALREADY GRADED A+| BRAND NEW VERSION€17,29
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Cannabis, Tobacco, and Vaping Final Set
QUESTIONS AND CORRECT DETAILED
ANSWERS {RATIONALES & IMAGES
INCLUDED} |ALREADY GRADED A+|
BRAND NEW VERSION
Problem Set 1: The Basics
Which term refers to the vegetative portion of a cannabis plant from a strain containing
low levels of THC?
Marijuana
Hemp
Hashish
CBD
Hemp
- comes from the vegetative portion of the cannabis plant that has low levels of THC
- possibly high levels of CBD
- comes from a particular strain of cannabis sativa
Marijuana is wrong
- comes from the flowering part of the cannabis plant
Hashish is wrong
CBD is wrong
- is made from hemp, not marijuana
Medical marijuana is a term for derivatives of the Cannabis sativa plant that are used to
ease symptoms caused by certain medical conditions. Medical marijuana is also known
,as medical cannabis. Cannabis sativa contains many active compounds. The best
known are delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD).
Brainpower
Read More
In what year did marijuana become outlawed at the federal level for all uses?
1961
1971
1972
2018
1971
- it became a Schedule I drug
1961 is wrong
- single convention on narcotic drugs
- included cannabis with opium and others
- prohibited production and supply other for medical purposes
2018 is wrong
- CBD from hemp is legal after 2018 farms bill
Which cannabinoids are psychoactive? Select all that apply
delta9-THC-acid
delta9-THC
CBD
CBD-acid
delta9-THC (tetrahydrocannabinol)
- there are 11 cannabinoids
-> only psychoactive cannabinoid is delta9-THC
-> delta9-THC and CBD are 2 cannabinoids
delta9-THC-acid is wrong
- is not psychoactive though
- converted to delta9-THC during heating or combustion
CBD is wrong
- is not psychoactive
- it reduces the psychoactive effects of THC
- concentration in street marijuana has dropped to near 0
- CBD acid is converted to CBD during heating and combustion
,Is THC effective as an analgesic?
yes
Ajulmec acid
synthetic analog of THC metabolite
cant cross BBB
What type of pain is CBD better for?
not effective for acute pain but very effective for inflammatory and neuropathic chronic
pain
Mechanism of CBD blocking pain
TRPV1
May block TNFa secretion (causes inflammation)
Role of FAAH in pain management
FAAH inhibitors block acute and chronic pain
FAAH deficient mics are less sensitive to pain
No tolerance to inhibition
Full FAAH inhibition and partial MAGL inhibition give analgesic effect
Role of MAGL in pain management
MAGL inhibitors block acute and chronic pain
Tolerance to MAGL inhibition
What type of pain is the CB2 receptor involved in?
acute
chronic
chronic
AM1710
CB2 agonist
reduces neuropathic pain
reduces TNFa
no tolerance built
COMPASS study
One group of patients self-dosed other group continued normal treatment
cannabis users reported significant decrease in pain
no difference in severe adverse events
FAAH inhibitor trial
did not work
no observation of reduced pain
osteoarthritis pain is spontaneous pain
Problem Set 4: Epilepsy and Neurodegenerative Disorders
THCs pro-convulsant effects are most likely mediated through which type of neuron?
GABAergic
Glutamatergic
Glutamatergic
- low-dose - 50mg/kg THC was pro-convulsant
-> low dose THC inhibits glutamatergic neurons which leads to decreased glutamate
and decreased anxiety
, Gabaergic is wrong
- high dose THC (200 mg/kg) is anti-convulsant
-> THC inhibits GABAergic neurons which will lead to decreased GABA and increased
anxiety
You take a blood sample from a long-term epilepsy patient immediately following a
seizure. What levels of endocannabinoids do you expect to find?
elevated
reduced
normal
normal
- endocannabinoid levels increase after induced seizure but in long-term epilepsy
patients there is no negative feedback loop so the levels are normal and do not change
Based on our current understanding, does CBD prevent seizures through its effects on
glutamatergic or GABAergic neurons?
glutamatergic
GABAergic
glutamatergic
- GPR55 antagonist which will prevent Ca2+ influx to glutamatergic neurons
What is the composition of Epidiolex?
THC
CBD
THC:CBD
Cannabis extract
CBD
- epidolex - is sublingual CBD with no THC
THC:CBD is wrong
- eg, Hemp Oil which is high CBD/ low THC
THCs effect on which intracellular molecule/ion has the most direct neuroprotective
effect?
Glutamate
GABA
Na+
K+
Ca2+
Ca2+
- Cannabinoid Neuroprotection
-> CB1 agonists which reduces excessive glutamate release - excessive glutamate
causes calcium accumulation/damage/death
Which drug would be the most likely to show positive effect in the treatment of MS?
CB1 agonist
CB2 agonist
CB1 antagonist
CN2 antagonist
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