100% tevredenheidsgarantie Direct beschikbaar na je betaling Lees online óf als PDF Geen vaste maandelijkse kosten
logo-home
Eerder door jou gezocht
Eerder door jou gezocht
logo
Cell Signalling (Biomedical Science) €13,36
In winkelwagen
Snel navigeren naar
Voorbeeld
  2.  
  3. Aston University, Birmingham (Aston)
  4.  
  5. Cells to Systems (BB4CTS)

College aantekeningen

Cell Signalling (Biomedical Science)
 0 keer verkocht
  • Vak
  • Cells to Systems (BB4CTS)
  • Instelling
  • Aston University, Birmingham (Aston)
  • Boek
  • Molecular Biology of the Cell (Seventh Edition)

The document provides a comprehensive overview of cell signalling, focusing on signal transduction and receptor tyrosine kinases. It covers various types of cellular communication such as contact-dependent, paracrine, synaptic, endocrine, and autocrine signalling. It details the role of receptors a...

[Meer zien]

Voorbeeld 2 van de 15  pagina's

Document informatie

  • 30 juni 2024
  • 15
  • 2023/2024
  • College aantekeningen
  • Dr zita balklava
  • Alle colleges

Onderwerpen

  • cell signalling
  • signal transduction
  • receptor tyrosine kinase
  • secondary messengers
  • g proteins
  • signalling cascades
  • gpcr activation
  • bio
  • biomed
  • biomedical science
  • g protein coupled receptor

Gekoppeld boek

book image

Titel boek:

Auteur(s):

  • Uitgave:
  • ISBN:
  • Druk:

Meer samenvattingen voor studieboek

  • DEELTOETS2 - CELLEN & WEEFSELS
  • Cellen en Weefsels (2024/2025) Deeltoets 1
  • Cellen en Weefsels (2024/2025) Deeltoets 2
Alles voor dit studieboek (5)

Geschreven voor

  • Aston University, Birmingham (Aston)
  • Onbekend
  • Cells to Systems (BB4CTS)
Alle documenten voor dit vak (8)

Verkoper

avatar-seller
ame03

Voorbeeld van de inhoud

Cells To Systems - Cell Signalling
Cell Signalling - Signal Transduction & Receptor Tyrosine Kinases

Cellular Communication:

 No cells exist in isolation (each cell needs to know what the neighbouring cells are doing)
 Signals are constantly produced
 Signals need to be constantly received, processed, interpreted and response has to be generated
 Signals are generally transmitted across the environment in the form of soluble/insoluble molecules
 These molecules must be detected and appropriate responses must be produced
 The biggest barrier to this process is the cell membrane

 The membrane is impermeable to large soluble molecules
 Some are transported across the membrane
 Others are detected outside of the cell through the receptor and a signal has to be transmitted/conveyed into the
cell

Receptors - Receive signalling from the outside of the cell

Different Modes For A Cell To Receive Stimuli:

1. Contact dependent
2. Paracrine signalling
3. Synaptic signalling
4. Endocrine signalling
5. Autocrine/Self-signalling

Contact Dependent:
For a signal to be received, 2 components are needed to start this

1. Signalling molecule
2. Receptor on the cell surface

In The Form Of How This Is Passed Is Different:

 Sometimes, both the receptor and the signalling molecule will be transmembrane proteins
 Signalling cell will have a molecule which is sitting on the plasma membrane
 Receiving cell will have a receptor which will be embedded in the membrane
 Both cells have to be in very close contact for the signal to be passed on from 1 cell to another

Paracrine Signalling:

 Secreting soluble molecules
 They can diffuse
 The cells that are in close neighbourhood (if they have the receptors for these ligands/signal molecules) can receive
signals
 The closer the responding cells are to a signalling cell, the stronger response they will produce as they receive most
of the signal there. However, this a short distance signalling

Synaptic Signalling:

 Specific form of cell signalling
 When we think of neurons, they have cell bodies, 1 axon which is going to emit signals and they have other signals
coming in through dendrites
 With the target cell, there is a special formation of a synapse
 From the axon they have molecules that are secreted and the target cell is going to receive them
 Sometimes the signals have to cross a very long distance e.g synaptic nerve to the foot
1

, Cells To Systems - Cell Signalling
Endocrine Signalling:

 The signalling molecules have to travel through the bloodstream to go to the target cell
 Can be a very long distance until they meet their target cell

Autocrine/Self-Signalling:

 A very specific type of signalling
 The same cell is secreting signals and receiving them




Receptors & Ligands:

 For signalling to be initiated, receptors and signalling molecules are needed
 If the cell does not express an appropriate receptor for certain types of signalling molecules, then the particular
signal cannot respond

Ligand - A molecule that binds to a receptor e.g. the ligand of the insulin receptor is insulin

 Some receptors will be very specific and can only bind to 1 type of signal, but for some receptors, they can bind to
different types of ligands
 There will be ligands which will be very specific and can only bind to 1 receptor, or there will be ligands that can
bind to multiple receptors
 Different ligands can produce different responses at the same receptor e.g. agonist/antagonist
 So-called receptors communicate signals to cells
 Thousands of receptors exist in humans

Ligands:
Detects a vast array of signals

 Dissolved gases (NO, CO, H2S)
 Peptides/Proteins
 Fatty acids
 Amino acids
 Retinoids
 Nucleotides

Receptors:

 Intracellular
 Cell surface (ion channel-, G protein- and enzyme- coupled

Single Transduction - Process where 1 type of signal is converted to another




The Plasma Membrane As Interaction Surface With The Surrounding Of A Cell:

2

Dit zijn jouw voordelen als je samenvattingen koopt bij Stuvia:

Bewezen kwaliteit door reviews

Bewezen kwaliteit door reviews

Studenten hebben al meer dan 850.000 samenvattingen beoordeeld. Zo weet jij zeker dat je de beste keuze maakt!

In een paar klikken geregeld

In een paar klikken geregeld

Geen gedoe — betaal gewoon eenmalig met iDeal, creditcard of je Stuvia-tegoed en je bent klaar. Geen abonnement nodig.

Direct to-the-point

Direct to-the-point

Studenten maken samenvattingen voor studenten. Dat betekent: actuele inhoud waar jij écht wat aan hebt. Geen overbodige details!

Veelgestelde vragen

Wat krijg ik als ik dit document koop?

Je krijgt een PDF, die direct beschikbaar is na je aankoop. Het gekochte document is altijd, overal en oneindig toegankelijk via je profiel.

Tevredenheidsgarantie: hoe werkt dat?

Onze tevredenheidsgarantie zorgt ervoor dat je altijd een studiedocument vindt dat goed bij je past. Je vult een formulier in en onze klantenservice regelt de rest.

Van wie koop ik deze samenvatting?

Stuvia is een marktplaats, je koop dit document dus niet van ons, maar van verkoper ame03. Stuvia faciliteert de betaling aan de verkoper.

Zit ik meteen vast aan een abonnement?

Nee, je koopt alleen deze samenvatting voor €13,36. Je zit daarna nergens aan vast.

Is Stuvia te vertrouwen?

4,6 sterren op Google & Trustpilot (+1000 reviews)

Afgelopen 30 dagen zijn er 66184 samenvattingen verkocht

Opgericht in 2010, al 15 jaar dé plek om samenvattingen te kopen

Begin nu gratis
€13,36
  • (0)
In winkelwagen
Toegevoegd