Dna gyrase antimicrobials - Study guides, Class notes & Summaries

1. A 28-year-old female with folliculitis is not responsive to a 10-day treatment course with penicillin. An enzyme produced by the etiologic agent is most likely responsible for this treatment failure. At which site on the molecule shown does this enzyme act to destroy penicillin? The structural integrity of the β-lactam ring in penicillins is essential for their antimicrobial activity. Many resistant strains of staphylococci produce a β-lactamase (penicillinase) that cleaves the β-lactam ...

Antimicrobials Part 3: Miscellaneous Antibacterial Drugs Fluoroquinolones “oxacins”: Broad-spectrum agents with multiple applications; Disrupt DNA replication and cell division; PO or IV; Resistance develops slowly but has become common in Neisseria gonorrhoeae Side Effects: generally mild but can cause tendon rupture (low risk)Usually affects Achilles tendon Contraindications: Avoid in patients younger than 18 years; Avoid in patients with myasthenia gravis; Risk to all patien...

MICRO BIOLO Antimicrobials Part 3 Miscellaneous Antibacterial Drugs Fluoroquinolones “oxacins”: Broad-spectrum agents with multiple applications; Disrupt DNA replication and cell division; PO or IV; Resistance develops slowly but has become common in Neisseria gonorrhoeae Side Effects: generally mild but can cause tendon rupture (low risk)Usually affects Achilles tendon Contraindications: Avoid in patients younger than 18 years; Avoid in patients with myasthenia gravis; Risk to all p...