Drug polymorphism - Study guides, Class notes & Summaries

Pharmacology Module #1,#2 & #3 EXAM REVIEW, pharmacology module 3, Adv Pharm 5334 UTA Exam 1 What are the four phases of pharmacokinetics? - - Absorption, distribution, metabolism, excretion Bioavailability - The extent of drug that becomes available to the body after absorption "Free Drug" - - The drug that is not bound to protein that is free to exert a therapeutic effect Nicotine is a? What (3) effects does it have? - - A CYP 450 inducer - Increase metabolism of drug and re...

Parmacogenetics - ANSWER the study of genetic differences in drug responses when referring to one gene Pharmacogenomics - ANSWER the study of variances in drug response when studying all genes Phenotype - ANSWER physical appearance/function from the genotype/environment Genetic polymorphism - ANSWER differences in alleles usually a single nucleotide variation that causes a person to respond differently to a drug. drug polymorphism - ANSWER effect of a patient's age, gender, size, body ...

Topology and functionally important residues of ABCG2 A monomer of ABCG2 consists of a 655 amino acid protein with a 250 amino acid intracellular N-terminal NBD, an uncharacterized linker region followed by six TMDs and associated intra and extracellular loops. Orange colours indicate where the experimental and predicted topology differ. A number of residues have been identified as significant including glycosylation site (green), stability affecting sites (red) and putative drug binding sit...

Katzung & Trevor's Pharmacology: Examination and Board Review INTRODUCTION 1. A 3-year-old is brought to the emergency department having just ingested a large overdose of tolbutamide, an oral antidiabetic drug. Tolbutamide is a weak acid with a pKa of 5.3. It is capable of entering most tissues, including the brain. On physical examination, the heart rate is 100/min, blood pressure 90/50 mm Hg, and respiratory rate 20/min. Which of the following statements about this case of tolb...

Parmacogenetics - ANSWER the study of genetic differences in drug responses when referring to one gene Pharmacogenomics - ANSWER the study of variances in drug response when studying all genes Phenotype - ANSWER physical appearance/function from the genotype/environment Genetic polymorphism - ANSWER differences in alleles usually a single nucleotide variation that causes a person to respond differently to a drug. drug polymorphism - ANSWER effect of a patient's age, gender, size, body ...

Psychopharmacology; Fundamentals of Drugs and Behavior Actual preparation test exam with Thorough and Correct Answers Updated 2024/2025 Increase in metabolizing liver enzymes following repeated drug use, can lead to 'pharmacokinetic tolerance'. Common with early-stage (pre liver damage) alcoholics. - correct answer Enzyme induction If two drugs that are metabolized by same enzyme are co-administered, they are active for longer and in higher concentrations. - correct answer Drug competiti...

therefore, increase CO but doesn't change BP bc not much effect on B2 albuterol - B-AR agonist Affinity: B2>>>> B1 Examples of drug/food- drug interactions in Type A ADRS - viagra and nitrates - severe hypotension warfarin and heparin - bleeding alcohol and acetaminophen - increase CYP2E1 toxin grapefruit - inhibits C450 which inc plasma drug conc Benadryl vs Advil PM minodoxil - treat hypertension but topically used for hair growth loniten vs rogaine Examples of Type A A...

Bias - correct answerAny systematic error in a measurement process black box warning - correct answera type of warning that appears in a drug's prescribing info and is required by the FDA to alert prescribers of serious adverse events that have occurred with the drug controlled substances - correct answerany drugs listed on one of the schedules of controlled substance act drug polymorphism - correct answervariation in response to a drug because of a patient's age, gender, size and/or ...

NU636 Quiz 1 1. A type B adverse drug reaction (ADR) is one that is unrelated to the pharmacologic action of the drug. They are precipitated by secondary pharmacologic actions of the drug, may be unpredictable, and may or may not be dose dependent. ADRs observed by practitioners should be reported to the FDA through which program? A. Vaccine Injury Program B. NIH Clinical Trial Monitoring Program C. MedWatch Program D. Patient Injury Program 2. Your patient has undergone genetic testing a...

Nursing 1140 Exam 2023 Questions and Answers 100% CorrectNursing 1140 Exam 2023 Questions and Answers 100% CorrectNursing 1140 Exam 2023 Questions and Answers 100% CorrectNursing 1140 Exam 2023 Questions and Answers 100% CorrectNursing 1140 Exam 2023 Questions and Answers 100% CorrectBias - ANSWER-Any systematic error in a measurement process black box warning - ANSWER-a type of warning that appears in a drug's prescribing info and is required by the FDA to alert prescribers of serious adver...