Ligand binding Study guides, Class notes & Summaries

ligand Correct Answer-a small molecule that binds specifically to a larger one (i.e., protein). For example, a hormone is the ligand for its specific protein receptor [a molecule bound reversibly by a protein. binding site Correct Answer-the location (crevice or pocket) on a receptor protein to which a ligand binds induced fit Correct Answer-The change in shape of the active site of an enzyme so that it binds more snugly to the substrate, induced by entry of the substrate. Renders the subs...

Psychopharmacology Drugs The Brain And Behavior 3rd Edition Meyer Nursing Test Bank Multiple Choice 1. refer(s) to specific molecular changes that occur when a drug binds to a particular target site or receptor, while are the resulting widespread alterationsin function. a. Drug action; therapeutic effects b. Side effects; drug effects c. Therapeutic effects; side effects d. Drug action; drug effects Answer: d Textbook Reference: Pharmacology: The Science of Drug Action 2. After drug administrati...

ligand - Is the word for a drug or a bio molecule a molecule that is reversibly bound to a protein, examples oxygen, endogenous neurotransmitters, hormones, drug molecules Binding site - A discrete portion of the protein that is complementary to the ligand in: - Shape and size - Charge distribution - Hydrophobic and hydrophilic regions ***Is involved in specific interaction, certain structural features must be present on the ligand for binding Induced fit - A complementary conformationa...

Week 3 Quiz #1 is C. 1. Volume neurotransmission refers to? The diffusion of neurotransmitter to nearby neurons. 2. Retrograde neurotransmissions refers to? The flow of neurotransmitter from postsynaptic neuron to presynaptic neuron 3. Use the following CYP450 table to hypothesize drug interactions and their clinical significance for a patient on clozapine who carbamazepine, a mood stabilizer? Clozapine levels would decrease, placing the patient at risk for re-emergence of psychotic sym...

A Hill coefficient (nH) of 2 indicates that: A) there is positive cooperativity in ligand binding. B) there are two ligand-binding sites. C) there is negative cooperativity in ligand binding. D) there is positive cooperativity in ligand binding and there are two ligand-binding sites. E) there is negative cooperativity in ligand binding and there are two ligand-binding sites. - A) there is positive cooperativity in ligand binding. A monoclonal antibody differs from a polyclonal antibody in...

Which of the following signaling types occurs during periods of development specifically for the secretion of growth factors? paracrine signaling Explain why a steroid hormone would require a carrier protein to transport it through the bloodstream. Steroid hormones are hydrophobic so they would need a carrier protein to carry it through the blood because carriers are hydrophilic Explain what a ligand is and give an example of one. A ligand is a molecule that has specificity for a given rece...

BIOMG 3300 Unit 3 Objectives Questions with Correct Answers. Fe3+ - Correct Answer doesn't allow for reversible binding to O2 Fe2+ when bound to 2 heme groups - Correct Answer can cause the formation of radicals, which are bad for the body Ligand - Correct Answer a molecule reversibly bound by a protein binding site - Correct Answer the place where a ligand binds to a protein complementary in size/charge/shape/hydrophilic/hydrophobic character induced fit - Correct Answer structura...

a ______ binds at a specific site on the protein called the ___________ correct answers ligand, binding site the binding of a ligand may cause __________ in the protein correct answers a conformational change the amount of oxygen can ________ correct answers limit an organisms size oxygen is poorly soluble in ______ correct answers aqueous solutions myoglobin correct answers monomeric protein hemoglobin correct answers tetrameric protein myoglobin is an example of ______ correc...

TEST BANK PATHOPHYSIOLOGY THE BIOLOGICAL BASIS FOR DISEASE IN ADULTS AND CHILDREN BY McCance Chapter 1: Cellular Biology MULTIPLE CHOICE 1. Which statement best describes the cellular function of metabolic absorption? a. Cells can produce proteins. c. Cells can take in and use nutrients. b. Cells can secrete digestive enzymes. d. Cells can synthesize fats. ANS: C In metabolic absorption, all cells take in and use nutrients and other substances from their surroundings. The remaini...

What factors affect binding affinity? Correct Answer-Shape, charge, H-bonding, hydrophobics reversible binding Correct Answer-the association of a protein with its ligan is concentration-dependent K_d Correct Answer-the concentration of ligand at which 1/2 of the protein is ligand-bound K_d = k_d / k_a or k_off / k_on also = k_-1 / k_1 Calculate fraction of protein bound to ligand Correct Answer-[L] / ([L] + K_d) affinity and concentration association Correct Answer-if they bind at...