Medicinal chemistry - Guides d'étude, Notes de cours & Résumés

Medicinal Chemistry Exam Review Solution Lipinski's Rules - ANS-An orally active drug should have the following: No more than 5 hydrogen bond donors No more than 10 hydrogen bond acceptors A molecular weight under 500 Da An octanol-water partition coefficient less than 5 First Pass Effect - ANS-When the majority of the active drug is metabolized the first time it goes through the liver(majority done here), gut wall, or portal vein. This necessitates that the drug must either increase ...

MEDICINAL CHEMISTRY AND MOLECULAR PHARMACOLOGY MCMP 442 Exam 2 2024 – QUESTIONS AND DETAILED CORRECT ANSWERS Which is the most likely reason that HIV-infected people with heterozygous HLA loci have a delayed progression to AIDS compared with patients who are homozygous at one or more HLA loci? A. The greater number of HLA alleles provides a wider variety of HLA molecules for presenting HIV-derived peptides to CD8 T cells even if HIV mutates during the course of infection. B. Heteroz...

Bps 337 - Medicinal Chemistry 3 Questions With Correct Answers chiral A molecule or carbon atom bonded to four different groups and without a plane of symmetry Put the hydrogen (smallest) away from you If it increases clockwise its R If counterclockwise, its S How can you tell if a molecule is R or S? True T or F: The L-amino acids are S-enantiomers -except cytesine primary structure of proteins The order in which the amino acids are linked together

Bps 337 - Medicinal Chemistry 1 Questions With Answers Pharmacophore the three-dimensional arrangement of atoms or groups of atoms responsible for the biological activity of a drug molecule drug compounds which interact with a biological system to produce a biological response True T or F: There is no perfect drug Penicillin - but cannot kill all known bacteria, resistant bacteria, many have severe allergy Morphine - but can result in tolerance, addiction, respiratory depression, dead...

Ethambutol - ️️It is a comparatively weak antitubercular drug; its principal use is as the secondary drug to avoid resistance problems: a. Rifampicin b. Isoniazid c. Ethambutol d. Pyrazinamide Amino group - ️️Responsible for the broad spectrum activity of amoxicillin and ampicillin a. Benzyl group b. Amino group c. Hydroxyl group d. Methyl group Isoniazid - ️️It is the most powerful and active antitubercular drug a. Rifampicin b. Isoniazid c. Ethambutol d. P...

MEDICINAL CHEMISTRY AND MOLECULAR PHARMACOLOGY MCMP 442 EXAM 1 2024 – QUESTIONS AND DETAILED CORRECT ANSWERS A bacterium that causes a common disease in a population that has been previously exposed to it is called _____. A. opportunistic B. Resistant C. Endemic D. Attenuated E. Commensal Correct Answer C. Endemic A term generally used to describe all white blood cells is _____. A. hematopoietic cells B. myeloid progenitor C. dendritic cells D. monocytes E. leukocytes Correct A...

MEDICINAL CHEMISTRY AND MOLECULAR PHARMACOLOGY MCMP 442 FINAL EXAM 2024 – QUESTIONS AND DETAILED CORRECT ANSWERS Which of the following statements is FALSE regarding the adaptive immune system or the innate immune response? a. The adaptive system responds before the innate response during an infection b. Somatic recombination only occurs in the adaptive response and NOT in the innate response c. The adaptive response will produce proteins that bind more specifically to a pathogen c...

MEDICINAL CHEMISTRY AND MOLECULAR PHARMACOLOGY MCMP 442 Exam 2 2024 – QUESTIONS AND DETAILED CORRECT ANSWERS Which is the most likely reason that HIV-infected people with heterozygous HLA loci have a delayed progression to AIDS compared with patients who are homozygous at one or more HLA loci? A. The greater number of HLA alleles provides a wider variety of HLA molecules for presenting HIV-derived peptides to CD8 T cells even if HIV mutates during the course of infection. B. Heteroz...

1.8 PHAR 523 Medicinal Chemistry Of Endocrinology Test With Complete Solution ...

ACE correct answersAngiotensin Converting Enzyme ACE hydrolyzes angiotensin I to angiotensin II correct answers•ACE is a relatively non-specific zinc protease •Zinc proteases catalyze the cleavage of a dipeptide from the carboxy terminus of a protein or a peptide (in the case of ACE, this is angiotensin I) •It uses Zinc as a cofactor what was used to study the function of ACE? what is ACE? correct answers-Carboxypeptidase A1 -ACE is a Membrane-bound enzyme that is difficult to iso...