Bmtcn chapter 1 - Study guides, Class notes & Summaries

BMTCN Chapter 1 Basic Concepts and Indications for Transplantation Which of the following is an example of a myeloid cell? A. Thymus-derived cells (T cells) B. Bone marrow-derived cells (B cells) C. Monocytes D. Natural killer cells - correct answer C. Monocytes Several factors affect immune reconstitution following hematopoietic stem cell transplantation (HSCT). These include all of the following EXCEPT: A. Recipient's response to conditioning regimen B. Viral infections C. Chronic ...

BMTCN - Chapter 6What are the types of cardiac diseases common post HSCT? What conditioning medications can cause these diseases? - correct answer Cardiomyopathy, arrhythmias, congestive heart failure - high dose Cytoxan and radiation causes this HTN/Dyslipidemia: Immunosuppression meds HTN/Hyperkalemia: Cyclosporine HTN/Hyperlipidemia and edema: Sirolimus How would you management cardiac disease in post-HSCT patients? - correct answer Assess risk factors, follow up testing (EKG, ...

BMTCN - Chapter 5 (intro and acute GVHD)What is graft vs host disease? - correct answer Donor T cells recognize antigens on cells in the recipients organs as foreign and mount an immunologic response What are the two categories of GVHD? What determines the category? - correct answer Acute and chronic. Clinical manifestations categorize GVHD What does acute GVHD present as? - correct answer Erythematous, maculopapular rash, nausea, vomiting, anorexia diarrhea, ileus, liver disease that occu...

BMTCN Review Chapter 4 - Transplant Preparative Regimens, Cellular Infusion, Acute Complications, and EngraftmentTRANSPLANT PREP REGIMENS - correct answer Treatment leading up to transplant Acronyms: Ara-C BCNU BU Cy DLT SCT TBI - correct answer Cytarabine Carmustine Busulfan Cyclophosphamide Dose limiting toxicity DStem cell transplant Total body irradiation Induction chemotherapy - correct answer The first treatment given for a disease. It is often part of a standard set of ...

BMTCN Chapter 5 Graft-versus-Host DiseaseT.R. is a 28-year-old woman with acute myeloid leukemia in her second complete remission who is admitted for a matched unrelated allogeneic stem cell transplantation. Her conditioning regimen is as follows: Myeloablation (busulfan/cyclophosphamide) and immunosuppression with tacrolimus and methotrexate (5 mg/m2 on days +1, +3, +6, and +11). She did not receive methotrexate on day +11 because of severe mucositis. Her transplant course was complicated...

BMTCN - Chapter 5 (intro and acute GVHD)What is graft vs host disease? - correct answer Donor T cells recognize antigens on cells in the recipients organs as foreign and mount an immunologic response What are the two categories of GVHD? What determines the category? - correct answer Acute and chronic. Clinical manifestations categorize GVHD What does acute GVHD present as? - correct answer Erythematous, maculopapular rash, nausea, vomiting, anorexia diarrhea, ileus, liver disease that occu...

BMTCN - Chapter 5 (chronic GVHD)What is chronic GVHD? - correct answer Late complication of HSCT effecting quality of life, immune mediated disorder. Must have at least one diagnostic manifestation of chronic GVHD or at least one distinctive sign confirmed by lab test. It can involve one or more organs. Failure to improve after at least 2 months or progression after 1 month of standard corticosteroid based immunosuppressive therapy What differs between chronic and acute GVHD? - correc...

BMTCN - Chapter 5 (chronic GVHD) What is chronic GVHD? - correct answer Late complication of HSCT effecting quality of life, immune mediated disorder. Must have at least one diagnostic manifestation of chronic GVHD or at least one distinctive sign confirmed by lab test. It can involve one or more organs. Failure to improve after at least 2 months or progression after 1 month of standard corticosteroid based immunosuppressive therapy What differs between chronic and acute GVHD? - corr...

Goal of Transplant - -Cure disease -Increase disease free survival Hematopoiesis - -Regulation, production and development of blood cells -Pluripotent Stem cells -Progenitor Stem Cells. -Myeloid and lymphoid lineage Myeloid progenitor cells mature into: - Megakaryocytes (platelets) Erythrocytes Mast cells Myeloblasts Lymphoid progenitor cells mature into: - Small lymphocytes (B cells/T cells) Natural Killer Cells B cells - -Develop in the bone marrow -Differentiate into plasma cells...

BMTCN Chapter 5: Graft-versus-Host Disease Already Passed T.R. is a 28-year-old woman with acute myeloid leukemia in her second complete remission who is admitted for a matched unrelated allogeneic stem cell transplantation. Her conditioning regimen is as follows: Myeloablation (busulfan/cyclophosphamide) and immunosuppression with tacrolimus and methotrexate (5 mg/m2 on days +1, +3, +6, and +11). She did not receive methotrexate on day +11 because of severe mucositis. Her transplant course w...