Cockayne syndrome Study guides, Class notes & Summaries

AMCB 6 Exam Questions with Correct Answers Xeroderma pigmentosum (XP) - Answer-Rare autosomal recessive disease Extreme sensitivity to UV light People with XP have defective nucleotide excision repair pathways Cockayne Syndrome - Answer--Another DNA repair deficiency like XP -Characterized by photosensitivity, premature aging, neurological symptoms, and early death -Defect in transcription-coupled repair -Said to arise from RNA pol molecules permanently stalled at sites of DNA damage ...

AMCB 6 Exam Questions with Correct Answers Xeroderma pigmentosum (XP) - Answer-Rare autosomal recessive disease Extreme sensitivity to UV light People with XP have defective nucleotide excision repair pathways Cockayne Syndrome - Answer--Another DNA repair deficiency like XP -Characterized by photosensitivity, premature aging, neurological symptoms, and early death -Defect in transcription-coupled repair -Said to arise from RNA pol molecules permanently stalled at sites of DNA damage ...

Nucleoside Analog Inhibitors Nucleoside analogs that lack 3'-OH group act as drugs that inhibit DNA replication -need to be converted into DNTP's before inhibiting DNA pol (Acyclovir- thymidine kinase; cytosine araC- treatment of leukemia; AZT- HIV therapy) Xeroderma Pigmentosum Skin sensitive to sunlight (prone to developing melanomas & squamous cell carcinomas) -UV of sunlight= thymine dimers in DNA -->easily repaired in normal individuals with NER Hereditary nonpolypo...

AMCB 6 Exam Questions with Correct Answers Xeroderma pigmentosum (XP) - Answer-Rare autosomal recessive disease Extreme sensitivity to UV light People with XP have defective nucleotide excision repair pathways Cockayne Syndrome - Answer--Another DNA repair deficiency like XP -Characterized by photosensitivity, premature aging, neurological symptoms, and early death -Defect in transcription-coupled repair -Said to arise from RNA pol molecules permanently stalled at sites of DNA damage tha...

AMCB 6 Exam Questions with Correct Answers Xeroderma pigmentosum (XP) - Answer-Rare autosomal recessive disease Extreme sensitivity to UV light People with XP have defective nucleotide excision repair pathways Cockayne Syndrome - Answer--Another DNA repair deficiency like XP -Characterized by photosensitivity, premature aging, neurological symptoms, and early death -Defect in transcription-coupled repair -Said to arise from RNA pol molecules permanently stalled at sites of DNA damage ...

AMCB 6 Exam Questions with Correct Answers Xeroderma pigmentosum (XP) - Answer-Rare autosomal recessive disease Extreme sensitivity to UV light People with XP have defective nucleotide excision repair pathways Cockayne Syndrome - Answer--Another DNA repair deficiency like XP -Characterized by photosensitivity, premature aging, neurological symptoms, and early death -Defect in transcription-coupled repair -Said to arise from RNA pol molecules permanently stalled at sites of DNA damage ...

AMCB 6 QUESTIONS AND ANSWERS Xeroderma pigmentosum (XP) - correct answer Rare autosomal recessive disease Extreme sensitivity to UV light People with XP have defective nucleotide excision repair pathways Cockayne Syndrome - correct answer -Another DNA repair deficiency like XP -Characterized by photosensitivity, premature aging, neurological symptoms, and early death -Defect in transcription-coupled repair -Said to arise from RNA pol molecules permanently stalled at sites of DNA damag...

DEE=daily energy expenditure energy required for BMR + physical activity Graves Disease Hyperthyroidism antibodies that stimulate the excess release of TH from the thyroid Charac: elevated BMR goiter tremors nontropical sprue=adult celiac disease reaction to gluten intestinal epithelium is damaged malabsorption results how many calories per kg when calculating a BMR 24cal/kg 50kg person= 24*50 excess calories needed for sedentary lifestyle 30% of BMR of p...

alpha-amanitin - Answer- Inhibits RNA poly II (mRNA synthesis) or RNA poly II in high concentrations 3' -> 5' exonuclease activity - Answer- All DNA polymerase What removes primers in eukaryotes - Answer- RNAase H What removes primers in prokaryotes - Answer- DNA poly I What 2 amino acids are not found in alpha helices - Answer- proline and glycine (bulky) Deamination of Cytosine yields? - Answer- Uracil Alkylated G pairs with? - Answer- T X-rays form what type of DNA d...

AMCB 6 Exam Questions with Correct Answers Xeroderma pigmentosum (XP) - Answer-Rare autosomal recessive disease Extreme sensitivity to UV light People with XP have defective nucleotide excision repair pathways Cockayne Syndrome - Answer--Another DNA repair deficiency like XP -Characterized by photosensitivity, premature aging, neurological symptoms, and early death -Defect in transcription-coupled repair -Said to arise from RNA pol molecules permanently stalled at sites of DNA damage th...