Ngr 6172 pharm exam1 Study guides, Class notes & Summaries
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NGR 6172 Pharm Exam1 with Complete Solutions
- Exam (elaborations) • 3 pages • 2023
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Aspirin- MOA - ANSWER-Binds irreversibly to cyclooxyrgenase-1 and 2 (COX 1 and 2) 
 
Decrease prostaglandin and thromboxane A2 production 
 
Plavix (clopidogrel) -MOA - ANSWER-Produg- irreversibly inhibits P2Y12 ADP-mediated platelet activation and aggregation 
 
Boxed warning of Plavix - ANSWER-conversion to active metabolite require (CYP 450 2C19) 
Poor metabolizers - higher CV events 
 
Plavix- avoid to take with what - ANSWER-2c19 inhibitors (omeprazole, esomeprazole) 
increased bleed 
 
pos...
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