Pk exam 2 Study guides, Class notes & Summaries

Start of clearance concepts ** Elimination/Clearance of a drugs is primarily mediated through what 2 things? Metabolism and excretion ** Clearance (CL) can be used to describe the process of drug elimination from the body (as an alternative to the word elimination). also represents a PK parameter that allows quantification of the speed at which a drug is eliminated from the body. What does CL allow you to do? o Decide how much drug should be administered o How frequen...

Kansas MPJE Exam 2023 Study guide. When does a pharmacist license need to be renewed in KS? - ANSWER Biennially, June 30th What are the CE requirements in KS? - ANSWER 30hours /2years, board approved, this number is prorated for the year that you are a new grad Intern hour requirement in KS? - ANSWER 1740 hours Intern license expiration in KS? - ANSWER 6 years Regulations on the sale of pseudoephedrine containing products specific to Kansas? - ANSWER Must be 18 or over to purchase Purch...

Which one of the following is the best definition of Clearance? a. Non-reversible removal of active drug from the systemic circulation b. Pre-systemic loss of active drug c. Steady target plasma concentration range d. Conversion of the administered drug into active drug A When a drug is converted to an inactive metabolite, it is considered to be cleared. T/F True You read that a drug is in the ECCS Class 1A. Therefore, you can predict that drug is absorbed by__________...

APK EXAM 2 STUDY GUIDE WITH COMPLETE SOLUTION!!

T/F Drug transfer is typically reversible or passive in transfer. True! Drug distribution refers to reversible transfer of drug between blood and extra vascular fluids and tissue of the body The extent and rate of distribution is dependent upon the ______ characteristics of the ______ and the _____ characteristics of the _____ physiological characteristics of the tissue and physicochemical characteristics of the drug Drug distribution driven by two main concepts: Ra...

____________ is the physiological effect of the drug on the body. - Efficacy - Toxicity Pharmacodynamics ____________ = minimum concentration required for the drug to be effective in 50% of the population Minimum effective concentration ____________ - minimum concentration required to produce toxic effects in 50% of the population minimum toxic concentration ____________ = range between the MEC and MTC therapeutic window ____________ = the ratio between MTC:ME...

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Pharmacodynamics what the drug does to the body Pharmacokinetics what body does to the drug 2D6 SUBSTRATES SPARTEINE & BUFURALOL 2D6 INHIBITORS QUINIDINE 2D6 INDUCERS NK 2C8 SUBSTRATES PACLITAXEL & REPAGLINIDE 2C8 INHIBITORS MONTEKULAST (SINGULAIR) 2C8 INDUCER RIFAMPICIN 2A6 SUBSTRATES NICOTINE & COUMARIN 2A6 INHIBITORS METHOXSALEN & TRANYLCYPROMINE 2A6 INDUCERS PHENOBARBATOL 2C9 SUBSTRATES TOLBUTAMIDE, S-WA...