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KNOBLE: A Knowledge-Based Approach for the Design and Synthesis of Readily Accessible Small-Molecule Chemical Probes To Test Protein Binding*
At the beginning of the last decade, potent high-throughput 
technologies stimulated the development of combinatorial 
chemistry as a productive source of candidate molecules 
suited for screening biological activity against putative drug 
targets. However, the sheer increase of readily available test 
compounds has not dramatically enhanced the efficiency of 
lead discovery.[1–3] 
As a consequence, compound selection for testing is 
moving increasingly from “optimally diverse” sets to tar...
- Exam (elaborations)
- • 5 pages •
At the beginning of the last decade, potent high-throughput 
technologies stimulated the development of combinatorial 
chemistry as a productive source of candidate molecules 
suited for screening biological activity against putative drug 
targets. However, the sheer increase of readily available test 
compounds has not dramatically enhanced the efficiency of 
lead discovery.[1–3] 
As a consequence, compound selection for testing is 
moving increasingly from “optimally diverse” sets to tar...
Phenomenon Based-Learning for Nigerian Higher Institutions: A new Curriculum Approach to meet the Challenges of the 21st Century
Curriculum is an organized set of 
formal education or process of training 
intentions. It is a four-step plan that comprises 
four phases (purpose, design, implementation 
and assessment (Federal Republic of Nigeria, 
2013). These definitions sequentially stress on 
plan that has a determined goal to achieve. 
Curriculum is the foundation of teaching and 
learning process. It is all-inclusive framework 
that encompasses development of educational 
program, planning teaching and learning 
proces...
- Exam (elaborations)
- • 10 pages •
Curriculum is an organized set of 
formal education or process of training 
intentions. It is a four-step plan that comprises 
four phases (purpose, design, implementation 
and assessment (Federal Republic of Nigeria, 
2013). These definitions sequentially stress on 
plan that has a determined goal to achieve. 
Curriculum is the foundation of teaching and 
learning process. It is all-inclusive framework 
that encompasses development of educational 
program, planning teaching and learning 
proces...
THE 3D XML BENCHMARK Mohammed Al-Badawi, Siobhán North, Barry Eagleston
In the context of XML technology, an XML 
benchmark is a tool for evaluating and comparing 
the performance of new XML developments with 
existing XML technology (Lu et al. 2005). Because 
of the nature of XML databases and the variety of 
different platforms used to store these databases (e.g. 
RDBMS and OO-RDBMS), the benchmarking 
process mainly examines the performance of the 
underlying storage-model, the associated query 
processor and the update handler (Lu et al. 2005). In 
ter...
- Exam (elaborations)
- • 8 pages •
In the context of XML technology, an XML 
benchmark is a tool for evaluating and comparing 
the performance of new XML developments with 
existing XML technology (Lu et al. 2005). Because 
of the nature of XML databases and the variety of 
different platforms used to store these databases (e.g. 
RDBMS and OO-RDBMS), the benchmarking 
process mainly examines the performance of the 
underlying storage-model, the associated query 
processor and the update handler (Lu et al. 2005). In 
ter...
Personalised and Context-based Access to Corporate Knowledge: a Multi-modal and Multi-model Solution Approach for Learning Activities
In general terms, global economy and companies world-wide are influenced by 
political, economic, social and technological forces. This explains their continuously 
changing environment, which in turn leads to a recurrent impact on society. Focusing 
on the technological viewpoint, modern companies are getting more knowledge 
intensive and set their investment efforts on technology-based services. Thus, workers 
are put under an enormous improvement pressure, because of (1) the expected hig...
- Exam (elaborations)
- • 8 pages •
In general terms, global economy and companies world-wide are influenced by 
political, economic, social and technological forces. This explains their continuously 
changing environment, which in turn leads to a recurrent impact on society. Focusing 
on the technological viewpoint, modern companies are getting more knowledge 
intensive and set their investment efforts on technology-based services. Thus, workers 
are put under an enormous improvement pressure, because of (1) the expected hig...
The Synthesis of a Model of Problem-Based Learning With the Gamification Concept to Enhance the ProblemSolving Skills for High Vocationa
Education is an important tool for developing the quality of a country’s citizens. 
The reason is that citizens are the cornerstone of a country’s development in various 
aspects from the advancement of science and technology to information technology. 
The advancement can be shown in the transformation which has occurred in society, 
the economy, culture, and the environment of the country. Therefore, the strategy for 
developing the quality of people can be seen in the reflection of T...
- Exam (elaborations)
- • 18 pages •
Education is an important tool for developing the quality of a country’s citizens. 
The reason is that citizens are the cornerstone of a country’s development in various 
aspects from the advancement of science and technology to information technology. 
The advancement can be shown in the transformation which has occurred in society, 
the economy, culture, and the environment of the country. Therefore, the strategy for 
developing the quality of people can be seen in the reflection of T...
Providing a teaching and learning open and innovative toolkit for evidence-based practice to nursing European curriculum (EBP e-Toolkit): Project rationale and design
INTRODUCTION 
Evidence-based practice (EBP) is a problem-solving approach 
to clinical decision-making that integrates the best available 
scientific evidence with clinical experience and patients’ 
preferences and values1 
. EBP is an instrument of great utility 
in making clinical decisions in nursing care, helping to reduce 
healthcare costs2 
 and variability in clinical practice, improving the 
quality of nursing care practice and patients’ health outcomes3 
, 
and increasing job...
- Exam (elaborations)
- • 7 pages •
INTRODUCTION 
Evidence-based practice (EBP) is a problem-solving approach 
to clinical decision-making that integrates the best available 
scientific evidence with clinical experience and patients’ 
preferences and values1 
. EBP is an instrument of great utility 
in making clinical decisions in nursing care, helping to reduce 
healthcare costs2 
 and variability in clinical practice, improving the 
quality of nursing care practice and patients’ health outcomes3 
, 
and increasing job...
A Deep Learning Approach for Identifying User Communities Based on Geographical Preferences and Its Applications to Urban and Environmental Planning
INTRODUCTION 
Currently, about fifty percent of the world’s population lives in urban areas and the forecast is 
that by 2050 this percentage will grow to approximately seventy percent [10]. As such, the greatest 
wave of city migration is yet to come and together with it a wide range of challenges raised by the 
need to improve the style and quality of life of a growing urban population. According to [10], a 
better understanding of city dynamics would allow for improved services as well as m...
- Exam (elaborations)
- • 24 pages •
INTRODUCTION 
Currently, about fifty percent of the world’s population lives in urban areas and the forecast is 
that by 2050 this percentage will grow to approximately seventy percent [10]. As such, the greatest 
wave of city migration is yet to come and together with it a wide range of challenges raised by the 
need to improve the style and quality of life of a growing urban population. According to [10], a 
better understanding of city dynamics would allow for improved services as well as m...
A Constraint-Based Evolutionary Learning Approach to the Expectation Maximization for Optimal Estimation of the Hidden Markov Model for Speech Signal Modeling
T 
HE HIDDEN Markov model (HMM) is the most successful and widely used statistical modeling technique for 
Manuscript received January 25, 2008; revised April 29, 2008 and July 18, 
2008. First published December 9, 2008; current version published January 15, 
2009. This paper was recommended by Associate Editor Y. Soon. 
S. Huda and J. Yearwood are with the Center for Informatics and 
Applied Optimization, University of Ballarat, Ballarat, Vic. 3350, Australia 
(e-mail: ; ; ood@ 
). 
R. Togner...
- Exam (elaborations)
- • 16 pages •
T 
HE HIDDEN Markov model (HMM) is the most successful and widely used statistical modeling technique for 
Manuscript received January 25, 2008; revised April 29, 2008 and July 18, 
2008. First published December 9, 2008; current version published January 15, 
2009. This paper was recommended by Associate Editor Y. Soon. 
S. Huda and J. Yearwood are with the Center for Informatics and 
Applied Optimization, University of Ballarat, Ballarat, Vic. 3350, Australia 
(e-mail: ; ; ood@ 
). 
R. Togner...
A blended approach to learning: added value and lessons learnt from students’ use of computer-based materials for neurological analysis
Introduction 
Physiotherapy students require observational and analytical skills to enable them to 
evaluate patient neurological disorders in the clinical setting. Large increases in numbers of students at the University of Birmingham have made the provision of opportunities for students to develop the practical skills needed for the clinical setting 
increasingly difficult. The School of Health Sciences used funding from the Learning 
Development Unit at the university to provide new teachin...
- Exam (elaborations)
- • 11 pages •
Introduction 
Physiotherapy students require observational and analytical skills to enable them to 
evaluate patient neurological disorders in the clinical setting. Large increases in numbers of students at the University of Birmingham have made the provision of opportunities for students to develop the practical skills needed for the clinical setting 
increasingly difficult. The School of Health Sciences used funding from the Learning 
Development Unit at the university to provide new teachin...
Deep Learning Based Homomorphic Secure Search-Able Encryption for Keyword Search in Blockchain Healthcare System: A Novel Approach to Cryptography
troduction 
A patient health record (PHR) is the basic and important information related to a 
patient’s history and related details. The digital healthcare system is considered as the 
platform for transferring and receiving patient health records. However, the existing digital 
healthcare systems rely on centralized servers, which are more prone to security breaches. 
Hence, the simplest solution is to integrate the digital healthcare system to blockchain 
technology due to its wide variety ...
- Exam (elaborations)
- • 29 pages •
troduction 
A patient health record (PHR) is the basic and important information related to a 
patient’s history and related details. The digital healthcare system is considered as the 
platform for transferring and receiving patient health records. However, the existing digital 
healthcare systems rely on centralized servers, which are more prone to security breaches. 
Hence, the simplest solution is to integrate the digital healthcare system to blockchain 
technology due to its wide variety ...