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KNOBLE: A Knowledge-Based Approach for the Design and Synthesis of Readily Accessible Small-Molecule Chemical Probes To Test Protein Binding*

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At the beginning of the last decade, potent high-throughput technologies stimulated the development of combinatorial chemistry as a productive source of candidate molecules suited for screening biological activity against putative drug targets. However, the sheer increase of readily available test compounds has not dramatically enhanced the efficiency of lead discovery.[1–3] As a consequence, compound selection for testing is moving increasingly from “optimally diverse” sets to tar...

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Phenomenon Based-Learning for Nigerian Higher Institutions: A new Curriculum Approach to meet the Challenges of the 21st Century

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Curriculum is an organized set of formal education or process of training intentions. It is a four-step plan that comprises four phases (purpose, design, implementation and assessment (Federal Republic of Nigeria, 2013). These definitions sequentially stress on plan that has a determined goal to achieve. Curriculum is the foundation of teaching and learning process. It is all-inclusive framework that encompasses development of educational program, planning teaching and learning proces...

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THE 3D XML BENCHMARK Mohammed Al-Badawi, Siobhán North, Barry Eagleston

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In the context of XML technology, an XML benchmark is a tool for evaluating and comparing the performance of new XML developments with existing XML technology (Lu et al. 2005). Because of the nature of XML databases and the variety of different platforms used to store these databases (e.g. RDBMS and OO-RDBMS), the benchmarking process mainly examines the performance of the underlying storage-model, the associated query processor and the update handler (Lu et al. 2005). In ter...

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Personalised and Context-based Access to Corporate Knowledge: a Multi-modal and Multi-model Solution Approach for Learning Activities

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In general terms, global economy and companies world-wide are influenced by political, economic, social and technological forces. This explains their continuously changing environment, which in turn leads to a recurrent impact on society. Focusing on the technological viewpoint, modern companies are getting more knowledge intensive and set their investment efforts on technology-based services. Thus, workers are put under an enormous improvement pressure, because of (1) the expected hig...

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The Synthesis of a Model of Problem-Based Learning With the Gamification Concept to Enhance the ProblemSolving Skills for High Vocationa

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Education is an important tool for developing the quality of a country’s citizens. The reason is that citizens are the cornerstone of a country’s development in various aspects from the advancement of science and technology to information technology. The advancement can be shown in the transformation which has occurred in society, the economy, culture, and the environment of the country. Therefore, the strategy for developing the quality of people can be seen in the reflection of T...

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Providing a teaching and learning open and innovative toolkit for evidence-based practice to nursing European curriculum (EBP e-Toolkit): Project rationale and design

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INTRODUCTION Evidence-based practice (EBP) is a problem-solving approach to clinical decision-making that integrates the best available scientific evidence with clinical experience and patients’ preferences and values1 . EBP is an instrument of great utility in making clinical decisions in nursing care, helping to reduce healthcare costs2 and variability in clinical practice, improving the quality of nursing care practice and patients’ health outcomes3 , and increasing job...

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A Deep Learning Approach for Identifying User Communities Based on Geographical Preferences and Its Applications to Urban and Environmental Planning

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INTRODUCTION Currently, about fifty percent of the world’s population lives in urban areas and the forecast is that by 2050 this percentage will grow to approximately seventy percent [10]. As such, the greatest wave of city migration is yet to come and together with it a wide range of challenges raised by the need to improve the style and quality of life of a growing urban population. According to [10], a better understanding of city dynamics would allow for improved services as well as m...

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A Constraint-Based Evolutionary Learning Approach to the Expectation Maximization for Optimal Estimation of the Hidden Markov Model for Speech Signal Modeling

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T HE HIDDEN Markov model (HMM) is the most successful and widely used statistical modeling technique for Manuscript received January 25, 2008; revised April 29, 2008 and July 18, 2008. First published December 9, 2008; current version published January 15, 2009. This paper was recommended by Associate Editor Y. Soon. S. Huda and J. Yearwood are with the Center for Informatics and Applied Optimization, University of Ballarat, Ballarat, Vic. 3350, Australia (e-mail: ; ; ood@ ). R. Togner...

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A blended approach to learning: added value and lessons learnt from students’ use of computer-based materials for neurological analysis

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Introduction Physiotherapy students require observational and analytical skills to enable them to evaluate patient neurological disorders in the clinical setting. Large increases in numbers of students at the University of Birmingham have made the provision of opportunities for students to develop the practical skills needed for the clinical setting increasingly difficult. The School of Health Sciences used funding from the Learning Development Unit at the university to provide new teachin...

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Deep Learning Based Homomorphic Secure Search-Able Encryption for Keyword Search in Blockchain Healthcare System: A Novel Approach to Cryptography

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troduction A patient health record (PHR) is the basic and important information related to a patient’s history and related details. The digital healthcare system is considered as the platform for transferring and receiving patient health records. However, the existing digital healthcare systems rely on centralized servers, which are more prone to security breaches. Hence, the simplest solution is to integrate the digital healthcare system to blockchain technology due to its wide variety ...

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