Genetics & Genomics module Imperial College London

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. These notes describe the ways in which genetic linkage maps and physical maps are generated and combined. I describe Genome-Wide Association Studies, which compare the genome sequenc...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. Description of genome engineering methods, particularly in mammals, and the principles underlying them. Nowadays, we can now modify genotypes of most organisms directly, quickly and ...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. How is genomic DNA expressed, and how is it that different cell types with the same genome receive different instructions? In these notes, I delve deeper into transcription, and how ...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. Focus on nuclear chromosomes: learn how 2 metres of DNA is somehow packaged into these tiny chromosomes and understand some key features of chromosomes that determine their structure...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. Focus on replication of the genome. Before a cell divides, the entire genome of 3 billion base pairs must first be copied: accurately, quickly and just once per cell cycle. During th...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. By comparing the sequences of different species we can identify sequences that have been conserved over long periods of evolution and so are likely to have important biological funct...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. What are Genetics and Genomics and why are they so important? As more and more was learned about genes, and the chromosomes that carry them, the importance of genomes emerged. Genomi...

Lecture notes from Imperial College London, Medical Biosciences BSc, 2nd year, genetics and genomics (GEN) module. Focus on genomic DNA. How do we know it is the DNA that genes are made of? In fact, for a long time it was thought that genes must be made of protein. We'll describe how this idea w...