UNIT 9 MN 553 Pharm questions with correct answers

Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to: Question options: A need to monitor drugs metabolized by 2D6 for toxicity Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors Decreased conversion of codeine to morphine by CYP 2D6 The need for lowered dosages of drugs, such as beta blockers Answer Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors Rifampin is a nonspecific CYP450 inducer that may: Question options: Lead to toxic levels of rifampin and must be monitored closely Cause toxic levels of drugs, such as oral contraceptives, when coadministered Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure