MMSC 436 Exam 3 with Correct Answers Already Passed

MMSC 436 Exam 3 with Correct Answers Already Passed therapeutic index - ️️ A quantitative measurement of the relative safety of a drug Comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity TI ratio in other words - ️️ Efficacy (pharmacology): safety (toxicity) without considering the nature of pharmacological or toxicological endpoints Is a high or low therapeutic index better? - ️️ A high Therapeutic Index (TI) is preferable for a drug to have favorable safety and efficacy profile Was frequently determined in animals as lethal dose of a drug for 50% of the population (LD50) divided by the minimum effective dose for 50% of the population (ED50), with human data,________ for 50% of the population is used (TD50) - ️️ toxic dose human studies equation - ️️ TI = TD50/ED50 animal studies equation - ️️ TI = LD50/ED50 which opioid has the highest TI? - ️️ Among the opioid painkillers, remifentanil is the most forgiving with a TI of 33,0