USMLE STEP 1 PHARMACOLOGY Questions and Answers with Complete Solutions 2024

USMLE STEP 1 PHARMACOLOGY Questions and Answers with Complete Solutions 2024 What are the major functions of the α1 receptor? - ANSIncrease vascular smooth muscle contraction, increase pupillary dilator muscle contraction (mydriasis), increase intestinal and bladder sphincter muscle contraction What are the major functions of the α2 receptor? - ANSDecrease sympathetic outflow, decrease insulin release, decrease lipolysis, increase platelet aggregation, decrease aqueous humor production What are the major functions of the β1 receptor? - ANSIncrease heart rate, increase contractility, increase renin release, increase lipolysis What are the major functions of the β2 receptor? - ANSVasodilation, bronchodilation, increase lipolysis, increase insulin release, decrease uterine tone (tocolysis), ciliary muscle relaxation, increase aqueous humor production What are the major functions of the M1 receptor? - ANSCNS, enteric nervous system What are the major functions of the M2 receptor? - ANSDecrease heart rate and contractility of atria What are the major functions of the M3 receptor? - ANSIncrease exocrine gland secretions (e.g., lacrimal, salivary, gastric acid), increase gut peristalsis, increase bladder contraction, increase bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation) What are the major functions of the D1 receptor? - ANSRelaxes renal vascular smooth muscle What are the major functions of the D2 receptor? - ANSModulates transmitter release, especially in the brain What are the major functions of the H1 receptor? - ANSIncrease nasal and bronchial mucus production, increase vascular permeability, contraction of bronchioles, pruritis, pain What are the major functions of the H2 receptor? - ANSIncrease gastric acid secretion What are the major functions of the V1 receptor? - ANSIncrease vascular smooth muscle contraction What are the major functions of the V2 receptor? - ANSIncrease H2O permeability and reabsorption in collect