D103 - Lecture 9&10 QUIZZES & Answers

1. Which of the following factors is NOT a component of the extracellular matrix (ECM)? A: Keratin B: Collagen C: Fibronectin D: Fibroblasts E: Proteoglycans - ANSWER A. Keratin 2. Which feature is shared between adherenjunctions and desmosomes? A: Both needs Ca2+to function B: Both connect the intermediate filaments of neighboring cells C: Both only contain cadherin andcytoskeleton D: Both promote cell migration E: Both have outside-in and inside-out signaling - ANSWER A: Both needs Ca2+to function 4. Why does a mutation in the oligomerization domain of E-cadherin promote the development of breast cancer? A: Because mutated cells can metastasize B: Because the keratin filamentsof neighboring cells are no longer connected C: Because Arp2/3-mediated actin dynamics are suppressed D: Because cells cannot adhere to the basal lamina E: Because this domain is the Ca2+binding site in the molecule - ANSWER A: Because mutated cells can metastasize 5. Which of the following statements best explains why a mutation in the extracellulardomain of an integrin β may block cell migration