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Pharm Tox Exam I Questions with Correct Answers
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Pharm Tox Exam I Questions with Correct Answers
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Pharm Tox Exam I Questions with Correct AnswersThe number one determining factor that determines the amount of drug
delivered to the tissues is _____. Correct Answer-perfusion rates
The parameter on a log dose response curve which describes the amount
of a response of effect of a given dose of a drug is known as _____.
Correct Answer-efficacy
Name two inhibitory neurotransmitters. Correct Answer-GABA, glycine
_____ must be completely eliminated from the diet in order to prevent a
possible hypertensive crisis with patients taking MAO-inhibitors.
Correct Answer-tyramine
The side effect profile of the selective serotonergic reuptake inhibitors
(SSRI) does NOT include weight _____. Correct Answer-gain
Most anxiolytic and sedative-hypnotic agents belong to a family of
drugs known as _____. Correct Answer-benzodiazepines
T/F With regards to lipid: water partition coefficient, the lower the
partition coefficient, the greater the absorption. Correct Answer-false;
increased coefficient = increased absorption
,T/F With regards to lipid: water partition coefficient, ionized, water-
soluble drugs are more readily absorbed. Correct Answer-false; fat
soluble drugs are more readily absorbed
Describe the correct order of neurotransmitter synthesis. Correct
Answer-tyrosine->L-DOPA->dopamine->norepi->epi
_____ is used for clinical depression and has been demonstrated to
decrease seizure threshold in selected patients. More recently it has been
demonstrated to decrease the cravings of nicotine. Correct Answer-
bupropion (wellbutrin)
Fluoxetine (Prozac), Sertraline (Zoloft), and Paroxetine (Paxil) all share
a common feature in that they selectively increase the levels of _____.
Correct Answer-5-hydroxytryptamine (serotonin)
A psychotherapeutic agent which has been approved by the FDA for
symptoms consistent with Obsessive-Compulsive disorder is _____.
Correct Answer-clomipramine (anafranil)
_____ would be seen in a patient whose muscarinic receptors were
stimulated when they received a direct acting cholinomimetic. Correct
Answer-bradycardia
_____ would be seen in a patient whose muscarinic receptors were
stimulated when they received an indirect acting cholinomimetic.
Correct Answer-miosis
, T/F Botulism causes increased release of ACh from the nerve terminus.
Correct Answer-false; botulism prevents the release of ACh
A beta one receptor antagonist would be used to treat _____. Correct
Answer-essential hypertension
T/F Organophosphate insecticides cause mydriasis. Correct Answer-
false; organophosphate insecticides cause pupillary constriction
A patient of yours presents with symptoms of a sleep disturbance. He
reports that over the past two weeks he has been unable to sleep for the
duration of the night. He falls asleep without difficulty, but then wakes
up 2 to 3 times during the night. The clinical picture is one suggestive of
_____. Correct Answer-parasomnia
Following first-pass metabolism, the blood levels of Amitriptyline
(Elavil) can now be evaluated by monitoring its active metabolite _____.
Correct Answer-nortriptyline (pamelor)
The intraneuronal degradation of catecholamines in the pre-synaptic
neuron is carried out by _____. Correct Answer-monoamine oxidase
Gamma-amino-butyric acid (GABA) functions by binding to cell
receptors to _____. Correct Answer-hyperpolarize the cell body by
increasing chloride conductance
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