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PHCY 402 – Vancomycin Exam Questions
With Correct Answers
Polar; large - answer✔vancomycin is too ___ to penetrate the outer membrane and too ___ to
pass through porin channels
vancomycin (vancocin, vancoled) - answer✔DOC for MRSA
PMC (c. diff super infection) - answer✔vancomycin is only used orally to treat ____
true - answer✔T/F: you must monitor serum levels of vancomycin to ensure efficacy and
reduce toxicity
polymerization (of the amino sugars) - answer✔Beta-lactams inhibit cross-linking;
glycopeptides inhibit ____
Lipid II - answer✔____ shuttles NAG-NAM precursors to the GT enzymes that form the
growing polymer
5 (very high affinity) - answer✔Vancomycin binds to Lipid II with __ hydrogen bonds
H-bond donor - answer✔Vancomycin resistant mutation removes a critical ____, which
decreases binding affinity by 1000 fold
red man syndrome - answer✔common side effect to vancomycin; red back/neck/face caused by
rapid histamine release into bloodstream if injected too fast
slow; antihistamines - answer✔vancomycin should be given in a (slow/fast) infusion, along
with ____ every 1-2 hours
Nephrotoxicity/ototoxicity - answer✔What rare side effects of vancomycin have an increased
chance when administered along with aminoglycosides?
myocardial infarction - answer✔in red man syndrome, histamine --> seizures --> _________
lipid appendage - answer✔lipoglycopeptides are just glycopeptides with the addition of a
_____
true - answer✔T/F: the lipid appendage addition in lipoglycopeptides counters some loss of
affinity in Vancomycin-
PHCY 402 – Vancomycin Exam Questions
With Correct Answers
Polar; large - answer✔vancomycin is too ___ to penetrate the outer membrane and too ___ to
pass through porin channels
vancomycin (vancocin, vancoled) - answer✔DOC for MRSA
PMC (c. diff super infection) - answer✔vancomycin is only used orally to treat ____
true - answer✔T/F: you must monitor serum levels of vancomycin to ensure efficacy and
reduce toxicity
polymerization (of the amino sugars) - answer✔Beta-lactams inhibit cross-linking;
glycopeptides inhibit ____
Lipid II - answer✔____ shuttles NAG-NAM precursors to the GT enzymes that form the
growing polymer
5 (very high affinity) - answer✔Vancomycin binds to Lipid II with __ hydrogen bonds
H-bond donor - answer✔Vancomycin resistant mutation removes a critical ____, which
decreases binding affinity by 1000 fold
red man syndrome - answer✔common side effect to vancomycin; red back/neck/face caused by
rapid histamine release into bloodstream if injected too fast
slow; antihistamines - answer✔vancomycin should be given in a (slow/fast) infusion, along
with ____ every 1-2 hours
Nephrotoxicity/ototoxicity - answer✔What rare side effects of vancomycin have an increased
chance when administered along with aminoglycosides?
myocardial infarction - answer✔in red man syndrome, histamine --> seizures --> _________
lipid appendage - answer✔lipoglycopeptides are just glycopeptides with the addition of a
_____
true - answer✔T/F: the lipid appendage addition in lipoglycopeptides counters some loss of
affinity in Vancomycin-
