Pmcol 344 Drug List Exam Study Guide.
Omeprazole - answerInhibits acid secretion in the stomach via the proton pump
Cimetidine - answerInhibits histamine and gastrin stimulated acid secretion via the H2
receptor.
Antacids - answerInorganic weak base salts that neutralize acid in the stomach.
A...
Atropine - answer✔Blocks Ach from contracting the muscle leading to relaxtion. Very
predictable symptoms
Morpine/Codine/Diphenoxalate - answer✔Opiates stop the release of Ach from nerve leading
to less contraction
Loperamide - answer✔Synthetic opioid agonist. Effects GI muscle and ENS to reduce
contraction
Methylcellulose - answer✔Polysaccharide polymer not broken down by gut. Binds water in the
gut reducing fluid volume. Forms hydrated bulky mass. Promotes peristaltic reflux
Lactulose - answer✔Disaccharide of fructose and glucose. Osmotically active molecules that
draws water into lumen.
Senna - answer✔Increase electrolytes and water secretion. Increases peristalsis. Directly
stimulates nerves in the myenteric plexus
Cholinomimetics/Cholinesterase inhibitors - answer✔Enhance GI contractions but they are
uncoordinated so they produce little peristaltic activity
Cisapride - answer✔5HT4 agonist. Targets presynaptic neurons that stimulate the myenteric
plexus. Causes Long QT syndrome due to blockage of HERG channels.
Tegaserod - answer✔5HT4 agonist. Targets presynaptic neurons that stimulate the myenteric
plexus
Pruclopride - answer✔Newest 5HT4 agonist. Targets presynaptic neurons that stimulate the
myenteric plexus
Lubiprostone - answer✔PGE1 analog. Increases cAMP via EP4 receptors to promote Cl
channels (CFTR) and promote fluid secretion
Sulfazalazine - answer✔Prodrug that is converted to 5-ASA. Scavenges free radicals and
inhibitis prostaglandin
Infliximab - answer✔Chimeric antibody that stop TNF-alpha from causing inflammation
Adalimumab - answer✔Humanized antibodies that stop TNF-alpha from causing inflammation.
Also suppresses formation of IL6/1. Causes cellular depletion via CD or ADCC
Galimumab - answer✔Humanized antibodies that stop TNF-alpha from causing inflammation
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