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[Show more]PMCOL 344 – Antivirals Exam Study Guide. 
Amantadine - answerProphylaxis and treatment of influenza A. Inhibits pH depending 
uncoating of virus by blocking M2. CNS effects at higher doses and not safe in pregnancy. 
Rimantadine - answerProphylaxis and treatment of influenza A. Inhibits pH dependi...
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Amantadine - answerProphylaxis and treatment of influenza A. Inhibits pH depending 
uncoating of virus by blocking M2. CNS effects at higher doses and not safe in pregnancy. 
Rimantadine - answerProphylaxis and treatment of influenza A. Inhibits pH dependi...
Pmcol 344 Midterm 2 Exam Questions With 
Correct Answers 
Mechlorethamine - answerNitrogen mustard alkylating agent: S-phase specific, bind 
covalently to DNA, mutagenic (given in single high dose) 
-Hodgkin's lymphoma 
-Dose-limiting: myelosuppression 
Chlorambucil - answerNitrogen mustard alkylat...
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Correct Answers 
Mechlorethamine - answerNitrogen mustard alkylating agent: S-phase specific, bind 
covalently to DNA, mutagenic (given in single high dose) 
-Hodgkin's lymphoma 
-Dose-limiting: myelosuppression 
Chlorambucil - answerNitrogen mustard alkylat...
PMCOL 344 Cancer Exam Study Guide. 
Nucleobases - answerPurine analogs that are converted into fake nucleotides that get 
incorporated into DNA and inhibit various enzymes. 
Camptothecin - answerTopoisomerase 1B inhibitor that forms a stable tertiary complex with 
TI-DNA complex. Causes DNA strand b...
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Nucleobases - answerPurine analogs that are converted into fake nucleotides that get 
incorporated into DNA and inhibit various enzymes. 
Camptothecin - answerTopoisomerase 1B inhibitor that forms a stable tertiary complex with 
TI-DNA complex. Causes DNA strand b...
Pmcol 344 Drug List Exam Study Guide. 
Omeprazole - answerInhibits acid secretion in the stomach via the proton pump 
Cimetidine - answerInhibits histamine and gastrin stimulated acid secretion via the H2 
receptor. 
Antacids - answerInorganic weak base salts that neutralize acid in the stomach. 
Al...
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Omeprazole - answerInhibits acid secretion in the stomach via the proton pump 
Cimetidine - answerInhibits histamine and gastrin stimulated acid secretion via the H2 
receptor. 
Antacids - answerInorganic weak base salts that neutralize acid in the stomach. 
Al...
PMCOL 344 – Immunity Exam Questions 
With Correct Answers 
Cyclosporine - answerCalcineurin inhibitor, effective immunosuppressive drugs. Lipid 
soluble antibiotic that forms a complex with cyclophilin A. Inhibits phosphatase activity of 
calcineurin and prevents NFAT nuclear translocation. Inhibi...
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With Correct Answers 
Cyclosporine - answerCalcineurin inhibitor, effective immunosuppressive drugs. Lipid 
soluble antibiotic that forms a complex with cyclophilin A. Inhibits phosphatase activity of 
calcineurin and prevents NFAT nuclear translocation. Inhibi...
PMCOL 344 Hematopoietic Exam Questions 
With Correct Answers 
Hydroxocobalamin - answerVitamin B12 therapy to treat anemia 
Darbopoietin - answerHyper-glycosylated form of Epo (recombinant human erythropoietin), 
longer half-life than others 
CERA - answerContinuous erythropoietin receptor activatio...
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With Correct Answers 
Hydroxocobalamin - answerVitamin B12 therapy to treat anemia 
Darbopoietin - answerHyper-glycosylated form of Epo (recombinant human erythropoietin), 
longer half-life than others 
CERA - answerContinuous erythropoietin receptor activatio...
PMCOL 344 – Metabolism Exam Study 
Guide. 
Simvastatin - answerStatin; reversibly inhhibits cholesterol biosynthesis by competitively 
inhibiting HMG-CoA reductase (rate-limiting step, causing upregulation of LDL receptors in 
liver, reduced production of VLDL and LDL, and increased HDL. Metaboliz...
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Guide. 
Simvastatin - answerStatin; reversibly inhhibits cholesterol biosynthesis by competitively 
inhibiting HMG-CoA reductase (rate-limiting step, causing upregulation of LDL receptors in 
liver, reduced production of VLDL and LDL, and increased HDL. Metaboliz...
PMCOL 344 Exam Questions With 
Correct Answers 
Gout 
what is it? 
characteristics? - answer-metabolic disorder leading to raised plasma uric acid levels 
-painful attacks of acute arthritis produced by deposition of sodium urate crystals in joints (big 
toe) 
urate crystals and immune response - an...
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Correct Answers 
Gout 
what is it? 
characteristics? - answer-metabolic disorder leading to raised plasma uric acid levels 
-painful attacks of acute arthritis produced by deposition of sodium urate crystals in joints (big 
toe) 
urate crystals and immune response - an...
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PMCOL 344 - Topoisomerase inhibitors. 
Exam Questions With Correct Answers 
Examples of DNA "cutters" topoisomerases inhibitors - answer* camptothecin and 
derivatives 
* anthracyclines 
* podophyllotoxin derivatives 
many topoisomerase inhibitors are - answerprodrugs 
DNA t...
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PMCOL 344 - Topoisomerase inhibitors. 
Exam Questions With Correct Answers 
Examples of DNA "cutters" topoisomerases inhibitors - answer* camptothecin and 
derivatives 
* anthracyclines 
* podophyllotoxin derivatives 
many topoisomerase inhibitors are - answerprodrugs 
DNA t...
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