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PHCY 508 Week 3: Hepatitis C Virus Questions with Correct Answers
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PHCY 508 Week 3: Hepatitis C Virus Questions with Correct Answers
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PHCY 508 Week 3: Hepatitis C Virus Questions withCorrect Answers
Hepatitis C Virus (HCV) Correct Answer-Most common blood-borne
pathogen in the United States (2.4 million with chronic infections). Is a
single-stranded RNA virus that is a common cause of Liver disease and
liver-related deaths.
Begins acute and progresses to chronic
NO AVAILABLE VACCINE
HCV Disease progression Correct Answer-Acute HCV --> Chronic
HCV --> Cirrhosis --> 15-20% risk of death following decompensated
Cirrhosis
HCV Genotypes Correct Answer-Genotype 1a and 1b
-75% of infections; Most common in US and worldwide
Genotype 2 and 3
-15-20% of infections
HCV Transmission Correct Answer-Blood-borne virus primarily
transmitted through parenteral exposures to infectious blood or body
fluids that contain blood.
Exposure Risks for HCV Correct Answer-Hemodialysis
Healthcare workers
Blood transfusion or solid organ transplantation
, Illicit drug use / injection
Acute v. Chronic HCV symptoms Correct Answer-Acute: Fatigue, loss
of appetite, RUQ pain, myalgia/arthralgia, Jaundice +/- pruritis, Dark
urine
Chronic: Fatigue, anxiety, anorexia, ascites, jaundice, variceal bleeding,
hepatic encephalopathy
Serologic testing for Hep C Correct Answer-Initial Screening:
-Serum Anti-HCV antibody (99% sensitive and specific; reactive within
12 weeks of exposure)
-May indicate acute OR chronic infection OR infection that has resolved
Confirmatory tests:
-Serum HCV RNA: Quantitative PCR-test that specifies the amount of
virus present
Hepatic Fibrosis Correct Answer-Inflammation associated with infection
leads to the production of collagen and other proteins
-Hallmark feature of chronic HCV infection that can progress to
cirrhosis
How do we determine the severity of Fibrosis in Hep C? Correct
Answer-Liver Biopsy
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