PHCY 631 – Gout Questions with Correct Answers
obesity, older age, male gender, alcohol, sugary beverages, red meat,
sedentary lifestyle Correct Answer-7 things associated with higher risk
of gout
dietary tissue nucleic acid synthesis Correct Answer-purines from which
uric acid is produced originate from:
- _____ purine
- conversion of _____ ____ ____ into purine nucleotides
-_____ of purine bases
600-800 Correct Answer-average human produces about ____ mg of
uric acid a day
PRPP synthetase Correct Answer-increased _____ ____activity causes
increased concentration of determinant of purine synthesis
HGPRT Correct Answer-deficiency of ______, which uses PRPP as co-
substrate, can cause increased uric acid production
proximal tubule Correct Answer-~ 90% filtered uric acid is reabsorbed
in the ____ ____
sodium Correct Answer-conditions that enhance ____ reabsorption
(dehydration) also result in increased ___ ___ reabsorption
,insulin resistance Correct Answer-by enhancing renal urate reabsorption,
___ ___ is also associated with gout
diuretics, ethanol, ethambutol, nicotinic acid, pyrazinamide, cytotoxic
drugs, salicylates, testosterone, cyclosporine Correct Answer-9 drugs
that are associated with gout
fever, pain, erythema, warmth, swelling, inflammation Correct Answer-
6 S/S of gout
symptoms Correct Answer-gout is diagnosed clinically by presence of
______
F Correct Answer-T/F asymptomatic hyperuricemia should be treated
acute Correct Answer-____ gout: monoarticular arthritis. frequently
attacks the first metatarsophalangeal joint, although other joints of the
lower extremities are also frequently involved. Affected joint is swollen,
erythematous, and tender.
interval Correct Answer-____ gout: asymptomatic period between
attacks
tophaceous Correct Answer-______ deposits of MSU crystals in soft
tissues. Complications include soft tissue damage, deformity, joint
, destruction, and nerve compression syndromes such as carpa tunnel
syndrome.
atypical Correct Answer-_____ gout: polyarthritis affecting any joint,
upper or lower extremity. may be confused with RA or OA
nephropathy Correct Answer-gouty _____. nephrolithiasis. acute and
CKD
night Correct Answer-gout attacks typically begin during day/night
stress, trauma, alcohol ingestion, infection, surgery, rapid lowering of
serum uric acid, certain drugs Correct Answer-7 things that might
precipitate a gout attack
tophi Correct Answer-small, whitish nodules of uric acid
aspiration synovial fluid MSU Correct Answer-definitive diagnosis of
gout requires ______ or _____ ____ at the affected joint and
identification of crystals of ____
septic Correct Answer-If symptoms or signs of infection are present,
such as white cells in synovial fluid, high fever, high WBC, multiple
joints affected, proper diagnosis and treatment is critical, as patients with
gout can have _____ arthritis.
obesity, older age, male gender, alcohol, sugary beverages, red meat,
sedentary lifestyle Correct Answer-7 things associated with higher risk
of gout
dietary tissue nucleic acid synthesis Correct Answer-purines from which
uric acid is produced originate from:
- _____ purine
- conversion of _____ ____ ____ into purine nucleotides
-_____ of purine bases
600-800 Correct Answer-average human produces about ____ mg of
uric acid a day
PRPP synthetase Correct Answer-increased _____ ____activity causes
increased concentration of determinant of purine synthesis
HGPRT Correct Answer-deficiency of ______, which uses PRPP as co-
substrate, can cause increased uric acid production
proximal tubule Correct Answer-~ 90% filtered uric acid is reabsorbed
in the ____ ____
sodium Correct Answer-conditions that enhance ____ reabsorption
(dehydration) also result in increased ___ ___ reabsorption
,insulin resistance Correct Answer-by enhancing renal urate reabsorption,
___ ___ is also associated with gout
diuretics, ethanol, ethambutol, nicotinic acid, pyrazinamide, cytotoxic
drugs, salicylates, testosterone, cyclosporine Correct Answer-9 drugs
that are associated with gout
fever, pain, erythema, warmth, swelling, inflammation Correct Answer-
6 S/S of gout
symptoms Correct Answer-gout is diagnosed clinically by presence of
______
F Correct Answer-T/F asymptomatic hyperuricemia should be treated
acute Correct Answer-____ gout: monoarticular arthritis. frequently
attacks the first metatarsophalangeal joint, although other joints of the
lower extremities are also frequently involved. Affected joint is swollen,
erythematous, and tender.
interval Correct Answer-____ gout: asymptomatic period between
attacks
tophaceous Correct Answer-______ deposits of MSU crystals in soft
tissues. Complications include soft tissue damage, deformity, joint
, destruction, and nerve compression syndromes such as carpa tunnel
syndrome.
atypical Correct Answer-_____ gout: polyarthritis affecting any joint,
upper or lower extremity. may be confused with RA or OA
nephropathy Correct Answer-gouty _____. nephrolithiasis. acute and
CKD
night Correct Answer-gout attacks typically begin during day/night
stress, trauma, alcohol ingestion, infection, surgery, rapid lowering of
serum uric acid, certain drugs Correct Answer-7 things that might
precipitate a gout attack
tophi Correct Answer-small, whitish nodules of uric acid
aspiration synovial fluid MSU Correct Answer-definitive diagnosis of
gout requires ______ or _____ ____ at the affected joint and
identification of crystals of ____
septic Correct Answer-If symptoms or signs of infection are present,
such as white cells in synovial fluid, high fever, high WBC, multiple
joints affected, proper diagnosis and treatment is critical, as patients with
gout can have _____ arthritis.
