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PHCY 512 - Exam 1 Topics Questions with correct Answers
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PHCY 512 - Exam 1 Topics Questions with correct Answers
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PHCY 512 - Exam 1 Topics Questions with correctAnswers
Where are drug targets located? Correct Answer-macromolecules,
within cells, embedded in cell membranes and outside of cells in various
body fluids
What are 3 physicochemical properties of a drug that may impact its
distribution to a target? Correct Answer-Size
Charge
Lipophilicity
Lost 4 purposes of excipients Correct Answer-1. Stability
2. Dissolution
3. Manufacturing speed
4. Manufacturing quality and flavoring
List 10 common dosage forms Correct Answer-Tablet
Capsule
Suppository
Solution
Suspension
Ointment
Cream
Gel
,Aerosol
Which two routes of administration are most commonly used for the
systemic administration of drugs? Correct Answer-Oral and intravenous
Define each letter in the acronym LADME Correct Answer-Liberation
Absorption
Distribution
Metabolism
Excretion
List 6 physicochemical factors related to drug disposition Correct
Answer-1. Solid state properties
2. Ionization
3. Solubility and dissolution
4. Partition coefficient
5. Mass transport and membrane passage
6. Complexation and protein binding
What are the major and minor metabolic organs? Correct Answer-Liver
(primary)
Intestinal epithelium
Kidneys
Lungs
, Skin
Placenta
What are the major and minor excretory pathways? Correct Answer-
Renal (primary)
Biliary
Saliva
Sweat
Tears
Breath
Breast milk
A drug product is made up of what 3 components? Correct Answer-1.
Drug substance
2. Inactive ingredient
3. Dosage form
Which organizations are responsible for maintaining the official
compendia for the United States? Correct Answer-The United States
Pharmacopeia (USP) and National Formulary (NF)
What are the 5 qualities of an ideal dosage form? Correct Answer-1. one
dose in a manageable size unit
2. Palatable or comfortable
3. Stable
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