Adv. Pharm NURS 8024 Week 1 Questions with complete solution 2024/2025 Adv. Pharm NURS 8024 Week 1
Pharmacokinetics - correct answer what the body does to the drug
Pharmacodynamics - correct answer what the drug does to the body
Toxicology - correct answer The undesirable effects ...
Adv. Pharm NURS 8024 Week 1
Pharmacokinetics - correct answer ✔what the body does to the drug
Pharmacodynamics - correct answer ✔what the drug does to the body
Toxicology - correct answer ✔The undesirable effects of chemicals on living
systems
Pharmacotherapeutics - correct answer ✔dynamic that achieves the desired
therapeutic effect of the drug without causing other undesirable effects
Legend drugs - correct answer ✔another name for prescription drugs
Pharmacogenomics - correct answer ✔the study of genetically determined
variations in the response to drugs
Pharmacologic Agonist - correct answer ✔agent binds to and activates the
receptor - directly or indirectly causing an effect, full or partial agonists
Pharmacological Antagonist - correct answer ✔Agent binds to receptor-
completes with other molecules and prevents binding by other molecules-it
inhibits other molecules from binding
Pro-drug - correct answer ✔An inactive percursor chemical-must be
abosorbed and distributed and converted to the active form of the drug by
biologic processes.
,What is ADME? - correct answer ✔Absorption
Distribution
Metabolism
Elimination
Absorption - correct answer ✔entry of pharmacologic agent into plasma
Distribution - correct answer ✔agent leaves the bloodstream and distributes
to interstitial and intracellular fluids
Metablosim - correct answer ✔chemical processes that occur to make the
drug useful in the bloodstream--done by the liver, kidney, or other tissue
Ellimination - correct answer ✔Leaving the body-via urine, bile, feces, lungs,
sweat, breast milk
2 Major Administration Routes - correct answer ✔1. Enteral -most common,
easy, cheap-BUT drug absorption pathways can be complicated
2. Parenteral-IV, fast, more expensive, once in-cannot get back
Enteral drug administration - correct answer ✔oral, sublingual, rectal
drug absorption pathways complicated
**First-pass metabolism can limit the amount of drug that enters systemic
circulation
influenced by food and other drugs
What is first pass metabolism? - correct answer ✔The concentration of drug
is greatly reduced BEFORE reaching systemic circulation. This mainly
, involves liver enzymes, but also includes gastric enzymes, gut wall enzymes,
and bacterial enzymes. Bioavaliability is reduced.
https://www.youtube.com/watch?v=BQQns7RAUzA
Parenteral drug administration - correct answer ✔-IV, IM, SubQ
- More control over actual dose of drug
- Directly into systemic circulation-bypass first pass metabolism
- used for drugs poorly absorbed by GI
-Rapid onset of action
-Disadvantage: cannot take the drug back, infection risk
Inhalation route of administration - correct answer ✔Rapid delivery, large
surface area, good for gases, aerolsols, respiratory drugs
Rectal Route of administration - correct answer ✔50% of circulatory drainage
BYPASSES portal circulation
Meaning: Less first pass effect
Drug Transport Methods: - correct answer ✔Passive diffusion (no E needed)
Active transport (requires E)
Endocytosis
Passive diffusion (simple diffusion) - correct answer ✔no energy needed,
related to concentration gradient across membrane, HIGHER concentration
goes to LOWER concentration
Active Transport - correct answer ✔requires energy (ATP), Able to move
drug from LOWER to HIGHER concentration
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