Aspirin Correct Answer-Non selective irreversible inhibitor of COX
Suppresses inflammation, analgesic, antipyretic (not in peds), prevention of platelet aggregation
In peds when taken with viral infection - Reyes syndrome; encephalopathy and fatty liver
Adverse effects: GI effects, bleeding, ren...
N398 Final Exam Drugs
Aspirin Correct Answer-Non selective irreversible inhibitor of COX
Suppresses inflammation, analgesic, antipyretic (not in peds), prevention
of platelet aggregation
In peds when taken with viral infection - Reyes syndrome;
encephalopathy and fatty liver
Adverse effects: GI effects, bleeding, renal impairment; salicylate
toxicity
Drug interactions: other NSAIDs, glucocorticoids, anticoagulants
Morphine and Oxycodone Correct Answer-Therapeutic uses = pain
relief
Mimic the action of endogenous opioid peptides primarily at Mu
receptor
AE = respiratory depression, constipation, orthostatic hypotension,
urinary retention, cough suppression, biliary colic, emesis, sedation,
euphoria
Amoxicillin Correct Answer-Broad spectrum, PO
Useful for gram positive and negative and some anaerobic
Renally eliminated - adjust does in renal dysfunction
AE - hypersensitivity, diarrhea
Piperacillin / tazobactum Correct Answer-Antipseudomonal penicillin
Broad spectrum coverage (gram pos, neg, and anaerobes)
Can cause hypersensitivity reactions and diarrhea
Kills pseudomonas aeruginosa (only certain ab will treat)
Cephalexin Correct Answer-PO first generation cephalosporin
Mainly works on gram + such as skin flora
Renally eliminated - adjust dose for renal patients
AE - nausea, vomiting, diarrhea
May take with food
Cefazolin is IV version used for surgical prophylaxis
Ceftriaxone Correct Answer-3rd generation cephalosporin
IV or IM
Some gram + and some gram - coverage
Not good for S. aureus or enterococcus
Great for strep. Pneumonia and N. gonorrhoeae coverage
Good CNS penetration
SE - hypersensitivities, bleeding
Contraindications - neonates (may displace bilirubin), not compatible
with calcium or phosphorus containing meds
, Doxycycline (tetracycline class) Correct Answer-Used to treat gram +
and gram -
Mycoplasma pneuomniae and chlamydia also tick borne illness
Can bind to cations - avoid administration with milk, antacids (wait 2
hrs)
Bacteriostatic and broad spectrum
Photo toxicity - wear sunscreen and avoid sun
Tooth discoloration (avoid in pregnancy or young children)
Associated with c. diff infections
Azithromycin (macrolides) Correct Answer-Reversibly binds to 50s
subunit inhibiting protein synthesis
Can cover atypical organisms such as mycoplasma, legionella, and
chlamydia
Bacteriostatic - can become cidal at higher concentrations
AE - nausea, vomiting, abdominal pain, some risk of QT prolongation
Good penetration into lungs
Metronidazole Correct Answer-Spectrum narrow - targets protozoa and
anaerobic bacteria
Inhibits nucleic acid synthesis to kill cells - bactericidal
Disulfiram reaction when taken with alcohol (blocks alcohol
dehydrogenase)
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