Advances in Experimental Medicine and Biology 1373
Julien Santi-Rocca Editor
Periodontitis
Advances in Experimental Research
,Advances in Experimental Medicine
and Biology
Volume 1373
Series Editors
Wim E. Crusio, Institut de Neurosciences Cognitives et Intégratives
d’Aquitaine, CNRS and University of Bordeaux, Pessac Cedex, France
Haidong Dong, Departments of Urology and Immunology, Mayo Clinic,
Rochester, MN, USA
Heinfried H. Radeke, Institute of Pharmacology & Toxicology,
Clinic of the Goethe University Frankfurt Main, Frankfurt am Main,
Hessen, Germany
Nima Rezaei, Research Center for Immunodeficiencies, Children’s
Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Ortrud Steinlein, Institute of Human Genetics, LMU University Hospital,
Munich, Germany
Junjie Xiao, Cardiac Regeneration and Ageing Lab, Institute
of Cardiovascular Science, School of Life Science,
Shanghai University, Shanghai, China
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,Julien Santi-Rocca
Editor
Periodontitis
Advances in Experimental Research
,Editor
Julien Santi-Rocca
Science and Healthcare for Oral Welfare
Toulouse, France
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine and Biology
ISBN 978-3-030-96880-9 ISBN 978-3-030-96881-6 (eBook)
https://doi.org/10.1007/978-3-030-96881-6
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,Preface
Research in periodontology is a blooming field: half the articles about peri-
odontitis referenced in Pubmed were published after 2009 (search:
“periodont*[title/abstract]”). This intensification of research came together
with its diversification and with the specialization of its growing branches. As
periodontitis is an inflammatory and infectious disease, fundamental research
pays a special attention to microbiology and physiopathology, as reflected in
this book. Furthermore, the crosstalk between periodontitis and other dis-
eases through their inflammatory and infectious components is being inten-
sively studied, highlighting the interest for integrative approaches for the
prevention and the treatment of all these conditions.
In evidence-based medicine, recommendations integrate results from
research and provide the practitioners safe and efficient tools for defined clin-
ical situations. However, when guidelines cannot be applied or fail, solutions
must be found, and the health practitioner should choose the best option
according to the state of the art. Clinicians must thus be literate in immunol-
ogy, microbiology, pathophysiology, and clinical research. As health practi-
tioners are not experts in all these fields, they should get intelligible data from
fundamental researchers to understand the guidelines and to be able to pro-
pose alternatives when they do not fit their practice or when the treatment is
not adapted to the patient. It is important that researchers also get feedback
from clinicians so their observations, in particular about therapeutic failure,
can be scientifically analyzed to lead to the evolution towards more adapted
guidelines including alternative options.
The aim of this book is to provide insights into the recent advances in
experimental research to make the bridge between current treatment guide-
lines and future directions, promoting both experimental and clinical research,
as well as public engagement with science. Thus, we have invited specialists
in experimental research on periodontitis to review the recent literature in
their field of expertise and to provide chapters presenting solid scientific evi-
dence to reach the widest audience through dedicated sections: “Highlights”
for researchers, “Considerations for Practice” for clinicians, and “Patient
Summary” for patients and non-specialists.
Chapters were peer-reviewed in a double-blinded process: manuscripts
were anonymized before submission to reviewers, and the identities of the
authors and reviewers were kept secret until final acceptance, when reviewers
could choose to be cited in the chapters.
v
,vi Preface
We thank the authors and the reviewers for their work, which provides a
strong frame to develop new research and to make decisions for periodontitis
therapeutic and prophylactic management.
Toulouse, France Julien Santi-Rocca
,List of Reviewers
Chapter 2
Thomas Van Dyke
Clinical and Translational Research, Forsyth Institute, Cambridge, MA, USA
Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine,
Boston, MA, USA, tvandyke@forsyth.org
Nailê Damé-Teixeira
Department of Dentistry, School of Health Sciences, University of Brasilia,
Brasília-DF, Brazil; nailedame@hotmail.com
Chapter 3
Reviewers asked to remain anonymous
Chapter 4
Reviewers asked to remain anonymous
Chapter 5
Mark Bonner
International Institute of Periodontology Victoriaville, QC, Canada; mark.
bonnerdmd@hotmail.com
Chapter 6
Cristiane Yumi Koga-Ito
Institute of Science and Technology, São Paulo State University/UNESP, São
José dos Campos, SP, Brazil. cristiane.koga-ito@unesp.br.
vii
,viii List of Reviewers
Chapter 7
Paulo Henrique Braz Silva
Department of Stomatology, School of Dentistry, University of São Paulo,
São Paulo, Brazil
Laboratory of Virology (LIM-52), Institute of Tropical Medicine of São Paulo,
School of Medicine, University of São Paulo, São Paulo; pbraz@usp.br
Chapter 8
Torsten Sterzenbach
Clinic of Operative and Pediatric Dentistry, Medical Faculty Carl Gustav
Carus, Technische Universität Dresden, Fetscherstraße 74, 01307,
Dresden, Germany; torsten.sterzenbach@uniklinikum-dresden.de
Chapter 9
Massimo Costalonga
Division of Periodontology, Department of Developmental and Surgical
Sciences, School of Dentistry, University of Minnesota, Minneapolis,
Minnesota, USA; costa002@umn.edu
Chapter 10
Reviewers asked to remain anonymous
Chapter 11
Reviewers asked to remain anonymous
Chapter 12
José Lopez-López
Department of Odontoestomatology, Faculty of Medicine and Health
Sciences (Dentistry), Bellvitge Campus, University of Barcelona,
Barcelona, Spain.
Oral Health and Masticatory System Group, Institut D'Investigació Biomédica
de Bellvitge (IDIBELL, Bellvitge Institute of Biomedical Research),
L’Hospitalet de Llobregrat, Barcelona, Spain.
Odontology Hospital University of Barcelona (HOUB), Barcelona, Spain;
18575jll@gmail.com.
, List of Reviewers ix
Chapter 13
Reviewers asked to remain anonymous
Chapter 14
Reviewers asked to remain anonymous
Chapter 15
Reviewers asked to remain anonymous
Chapter 16
Marie-Eve Bezzina
Private practice, Nice, France; marieeve.bezzina@gmail.com
Chapter 17
Reviewers asked to remain anonymous
Chapter 18
Reviewers asked to remain anonymous
Chapter 19
Rok Gašperšič
Department of Oral Medicine and Periodontology, Faculty of Medicine,
University of Ljubljana, Ljubljana, Slovenia; rok.gaspersic@mf.uni-lj.si
Chapter 20
Pierre-Yves Collard-Dutilleul
LBN, Université de Montpellier, Montpellier, France; pierre-yves.collart-
dutilleul@umontpellier.fr
Jeffrey Gimble
Obatala Sciences Inc., New Orleans, LA, USA.
