Exam (elaborations)
NUR 641E Midterm Study Guide questions with correct answers
- Course
- NURS 630
- Institution
- Maryville University Of St. Louis
NUR 641E Midterm Study Guide questions with correct answers
[Show more]
Content preview
NUR 641E Midterm Study Guide questions withcorrect answers
Prodrug Correct Answer-An inactive drug dosage form that is converted
to an active metabolite by various biochemical reactions once it is inside
the body.
-Cytochrome P450
-Ex. Aspirin, psilocybin, heroin
Bioavailability Correct Answer-the rate at and the extent to which a
nutrient is absorbed and used
-Affected by route of administration and drug dosage
-Drug clearance (rate drug leaves circulation)
-Steady state concentration
-Affected by chemical stability, solubility, and first pass
Steady state (of a drug) Correct Answer-stable level of drug in the body,
occurs in 5 half lives of the drug
-rate of drug being added to system is equal to amount being eliminated
from system
Pharmacokinetics Correct Answer-The process by which drugs are
absorbed, distributed within the body, metabolized, and excreted.
-what the body does to the drug
,First pass Correct Answer-the fact that a medication in the GI tract
passes through the liver before entering other organs
does not Correct Answer-bioequivalence does/does not affect
bioavailability
Bioequivalence Correct Answer-relative therapeutic effectiveness of
chemically equivalent drugs.
Bioavailability (is affected by) Correct Answer--chemical instability
-solubility
-first pass metabolism
Cytochrome P450 Correct Answer--enzymes that function to metabolize
potentially toxic compounds, including drugs and products of
endogenous metabolism such as bilirubin, principally in the liver.
-genetics influence presence of enzymes
-affects metabolism of warfarin, antidepressants, antiepileptics, and
statins.
-the levels of these drugs are higher when taken with certain drugs that
are inhibitors (ex. warfarin with omeprazole) because there is
competition for enzyme metabolism.
-inducers lead to decreased plasma concentration of drug.
, cytochrome p450 inducer Correct Answer-An inducer increases the
metabolism of a substrate resulting in a decreased level or effect of the
substrate
cytochrome p450 inhibitor Correct Answer-An inhibitor decreases the
metabolism of a substrate resulting in an increased level or effect of the
substrate.
Clopidogrel Correct Answer-prodrug that must be activated by hepatic
CYP2C19 metabolism; individuals who are poor metabolizers may not
form the active metabolite and have reduced antiplatelet response
half-life (determines) Correct Answer-how often a drug is administered
4-5 Correct Answer-steady state is reached in _-_ times the half-life
Warfarin (MOA) Correct Answer--Vitamin K antagonist
-Factors II, VII, IX, X
-takes several days to take effect
-monitor INR
Vitamin K Correct Answer-warfarin antidote
Heparin (MOA) Correct Answer--rapid anticoagulation by binding with
antithrombin III and inhibits factors IXa, Xa, XIIa, and XIII
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller cracker. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $16.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67474 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now