PHAR3816 Cardiovascular & Renal Medicine questions with correct answers
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Course
RN- Nursing
Institution
RN- Nursing
Beta Blockers MOA Correct Answer-'-olol'
MOA: Blocks binding of NE and E to beta receptors and inhibit Ca influx
-Decrease HR, decrease heart contractility, vasodilation, slows conduction through AV node
Avoid: Asthma/COPD and bradycardia
Indicated: Angina
Calcium Channel Blockers Correct An...
PHAR3816 Cardiovascular & Renal Medicine
questions with correct answers
Beta Blockers MOA Correct Answer-'-olol'
MOA: Blocks binding of NE and E to beta receptors and inhibit Ca
influx
-Decrease HR, decrease heart contractility, vasodilation, slows
conduction through AV node
Avoid: Asthma/COPD and bradycardia
Indicated: Angina
Calcium Channel Blockers Correct Answer-'-dipine'
MOA: Block L-type calcium channels and influx of calcium to cause
cardiac contraction
-Decrease HR, decrease heart contractility, vasodilation
Diuretics Correct Answer-MOA: decrease blood volume through
increase urine output by the kidney
Loop diuretics (frusemide): Inhibits Na-Cl-K co-transporter in thick
ascending limb (reabsorption 25% Na) leading to less water
reabsorption, increase diuresis and natriuresis
Thiazide diuretics: Inhibit Na-Cl transporter in distal tubule
(reabsorption 5% Na) (1st line when over 65yrs)
Angiotensin Receptor Blockers Correct Answer-'-sartan'
Block binding of ANGII at AT1R receptor
Cholesterol lowing methods Correct Answer-1. Statins
2. PCSK9 inhibitors (Evolocumab)
3. ApoB or microsomal transport protein inhibitors
4. Reducing intestinal absorption of cholesterol (diet, resins
(Colystyramine, tertaethylpentamine))
5. Azetidinones (ezetimibe) NPC1L1 inhibitor
Type 1 Statins Correct Answer-Mevastatin, Simvastatin, Lovastins
Contain (lactone ring) beta-hydroxy delta ring that must be hydrolysed
Type 2 Statins Correct Answer-No lactone ring and already active
Statin MOA Correct Answer-1. Block conversion of HMG-CoA to
mevalonate by competing with HMG-CoA for the binding of HMG-CoA
reductase
2. Increase LDL receptor expression and decrease free LDL
3. Inhibit GTPase responsible for vascular endothelial inflammatory
response
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