Lecture notes

Advanced Blood Sciences notes - Erythropoiesis - 4th year Bachelor - biomedical sciences

0 purchase

Module
Biomedical Sciences

Institution
Glasgow Caledonian University (GCU)

Notes from the course of Prof. Bartholomew about the erythropoiesis and pathologies associated with it.

[Show more]

Preview 3 out of 20 pages

View example

Uploaded on March 9, 2021
Number of pages 20
Written in 2018/2019
Type Lecture notes
Professor(s) Prof. christopher bartholomew
Contains Advanced blood sciences - erythropoiesis

£6.01

Add to cart

Add to wishlist

100% satisfaction guarantee
Immediately available after payment
Both online and in PDF
No strings attached

RED CELL PRODUCTION AND ASSOCIATED PATHOLOGIES

ERYTHROCYTOSIS AND POLYCYTHAEMIA

Mature blood cells are derived from stem and progenitor cells.

The mature cells are found in peripheral blood whereas cells at other
stages of the haematopoiesis are normally found in bone marrow.

The haematopoietic stem cells (HSCs) are rare. These cells can self-renew
or give rise to more differentiated cells when they divide. The HSCs can
be divided into long term and short term cells.

They give rise to common lymphoid (CLP) and common myeloid (CMP)
progenitor cells which are precursors of all lymphoid and myeloid cells
respectively.

The CMP cells give rise to megakaryocyte erythrocyte precursors (MEP)
and granulocyte macrophage precursor (GMP) cells which then give rise to
lineage specific cells such as megakaryocyte (MkP) and erythrocyte (ErP)
precursor cells.

,Differentiation cascade allows amplification of cell number.

As cell progress through the differentiation cascade they progressively
lose the capacity to self-renew and become more differentiated until they
finally become fully differentiated.

Along with this their ability to divide changes significantly. Stem cells are
rare and divide rarely. The progenitor and precursor cells have an
enormous capacity for cell division.

This allows the production of a large number of cells that are required
throughout lifetime in blood. As cells become fully differentiated they lose
the capacity to divide. These cells perform their biological function until
they die and are then replaced by more differentiated cells to maintain
homeostasis.

The earliest restricted erythroid progenitors arise from MEPs and are
characterised by the ability to form BFU-Es (burst forming units) in
semi solid cultures under specific conditions.

The BFU-E is a large colony containing thousands hemoglobinized cells.
BFU-E respond to EPO, stem cell factor (SCF), insulin growth factor 1
(IGF1), corticosteroids.

, They also divide slowly and give rise to rapidly proliferating CFU-Es
(colony forming unit). In the presence of certain factors (eg.
Corticosteroids), BFU-Es undergo extended self-renewal before becoming
CFU-Es. (BFU + CFU – intermediate cells)

The bone marrow microenvironment supports haemopoiesis

These are all components of microenvironment of bone marrow. Ligands
+ receptors interaction supports survival and differentiation of these
intermediate cells.

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller krzysztoflipiec. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £6.01. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

68175 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 15 years now

Start selling

Seller

Other ·