Lecture notes
Lipid therapies
- Module
- Medicine
- Institution
- Queens University Belfast (QUB)
Pathology and pharmacology
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LIPID THERAPYLowering LDL cholesterol is the main aim
Lifestyle for lipids
Portfolio diet
Minimis is e dietry fat replace saturated with mono
, unsaturated fat
Wholegrain rarities of
starchy food
Reduce sugar intake
Exercise stop smoking etc
Drugs in common use
1 HMG CoA reductase inhibitors statins
HMG CoA reductase is involved in
the Rate limiting step of cells producing
their own cholesterol If inhibited
cells have to take LDL from the blood
Cell requirements are met and
blood CDL falls
Statin potency t
Rosuvostatin Atorvastatin Sim vastatin Pravastatin
Generally given at
night extensively metabolised
Ro Su Vostatin t Pravastatin are hydrophilic Affects tolerance
side effects good at lowering LDL
Major adverse effects
Generally well tolerated
Muscle pain more
rarelymyositis in f lammed muscles or
rhabdomyolis is muscle breakdown kidney failure G1
disturbance Liver enzyme abnormalities
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