MARYVILLE PSYCHOPHARMACOLOGY, EXAM 1
REVIEW QUESTIONS
How many dopamine pathways in the brain? - Answer -5 but only 4 associated with
schizophrenia
Nigrostriatal Dopamine Pathway controls - Answer -motor function and movement (part
of EP NS)
Nigrostriatal Dopamine Pathway dopamine excess - Answer -Hyperkinetic movements
such as tics/dyskinesias
mesolimbic dopamine pathway controls - Answer -Pleasure, reward, euphoria of drug
abuse and reinforcing behavior
Mesolimbic dopamine pathway excess - Answer -delusions and hallucinations - positive
symptoms of schizophrenia or SE of illicit drugs
Mesocortical Dopamine Pathway controls - Answer -cognitive and affective symptoms
Mesocortical Dopamien Pathway deficiency - Answer -decreased cognition and flat
affect in Schizophrenia
Tuberinfundibular Dopamine Pathway controls - Answer -prolactin secretion into
circulation
Dopamine _______________________ prolactin secretion - Answer -inhibits
Positive Symptoms of Schizophrenia - Answer -Delusions, Hallucinations, Disorganized
speech, Disorganized behavior, catatonia, agitation
Positive symptoms of schizophrenia arise from - Answer -mesolimbic dopamine
pathway
Negative symptoms of schizophrenia - Answer -Alogia, asociality, affective blunting,
anhedonia, and avolition (5 A's)
Alogia is - Answer -poverty of speech, uses few words
Affective Blunting is - Answer -reduced range of emotions (feeling numb inside)
Asociality is - Answer -reduced social drive/interaction, little sexual interest, and few
friends
Anhedonia is - Answer -inability to experience pleasure
, Avolition is - Answer -lack of motivation
Negative symptoms arise from the - Answer -mesocortical pathway
Affective Symptoms are - Answer -Depressed mood, guilt, tension, anxiety, irritability,
and worry
Affective symptoms arise from the - Answer -ventromedial prefrontal cortex
Cognitive Symptoms of schizophrenia are - Answer -prioritizing, serial learning,
problem solving, focusing and sustaining attention, maintaining goals, and modulating
social behavior based on social cues, impaired verbal fluency
Cognitive symptoms arise from the - Answer -dorsolateral prefrontal cortex
Dorsolateral prefrontal cortex - Answer -cognitive symptoms
Nucleus accumbens - Answer -negative symptoms/reward circuits
Substantia nigra - Answer -motor function and movement
Mesolimbic - Answer -positive symptoms such as auditory hallucinations and delusions
Orbital front cortex - Answer -Aggressive symptoms
Flat affect and no emotion stems from what pathway - Answer -mesocortical
Delusions, hallucinations stems from what pathway - Answer -mesolimbic
Dopamine Hypothesis - Answer -The dopamine pathway plays an important role in
emotional behaviors - and positive symptoms in schizophrenia
Drugs that increase dopamine will - Answer -increase or produce positive symptoms of
psychosis - delusions and hallucinations
Drugs that decrease dopamine will - Answer -decrease or stop positive symptoms
Antipsychotics that decrease positive symptoms block __________ - Answer -D2
receptor
Cocaine/Meth release dopamine causing _______________ - Answer -psychosis that
is hard to differentiate from positive symptoms of schizophrenia
True/False: No one knows exactly how neurotransmitters and how they relate to
schizophrenia - Answer -True
REVIEW QUESTIONS
How many dopamine pathways in the brain? - Answer -5 but only 4 associated with
schizophrenia
Nigrostriatal Dopamine Pathway controls - Answer -motor function and movement (part
of EP NS)
Nigrostriatal Dopamine Pathway dopamine excess - Answer -Hyperkinetic movements
such as tics/dyskinesias
mesolimbic dopamine pathway controls - Answer -Pleasure, reward, euphoria of drug
abuse and reinforcing behavior
Mesolimbic dopamine pathway excess - Answer -delusions and hallucinations - positive
symptoms of schizophrenia or SE of illicit drugs
Mesocortical Dopamine Pathway controls - Answer -cognitive and affective symptoms
Mesocortical Dopamien Pathway deficiency - Answer -decreased cognition and flat
affect in Schizophrenia
Tuberinfundibular Dopamine Pathway controls - Answer -prolactin secretion into
circulation
Dopamine _______________________ prolactin secretion - Answer -inhibits
Positive Symptoms of Schizophrenia - Answer -Delusions, Hallucinations, Disorganized
speech, Disorganized behavior, catatonia, agitation
Positive symptoms of schizophrenia arise from - Answer -mesolimbic dopamine
pathway
Negative symptoms of schizophrenia - Answer -Alogia, asociality, affective blunting,
anhedonia, and avolition (5 A's)
Alogia is - Answer -poverty of speech, uses few words
Affective Blunting is - Answer -reduced range of emotions (feeling numb inside)
Asociality is - Answer -reduced social drive/interaction, little sexual interest, and few
friends
Anhedonia is - Answer -inability to experience pleasure
, Avolition is - Answer -lack of motivation
Negative symptoms arise from the - Answer -mesocortical pathway
Affective Symptoms are - Answer -Depressed mood, guilt, tension, anxiety, irritability,
and worry
Affective symptoms arise from the - Answer -ventromedial prefrontal cortex
Cognitive Symptoms of schizophrenia are - Answer -prioritizing, serial learning,
problem solving, focusing and sustaining attention, maintaining goals, and modulating
social behavior based on social cues, impaired verbal fluency
Cognitive symptoms arise from the - Answer -dorsolateral prefrontal cortex
Dorsolateral prefrontal cortex - Answer -cognitive symptoms
Nucleus accumbens - Answer -negative symptoms/reward circuits
Substantia nigra - Answer -motor function and movement
Mesolimbic - Answer -positive symptoms such as auditory hallucinations and delusions
Orbital front cortex - Answer -Aggressive symptoms
Flat affect and no emotion stems from what pathway - Answer -mesocortical
Delusions, hallucinations stems from what pathway - Answer -mesolimbic
Dopamine Hypothesis - Answer -The dopamine pathway plays an important role in
emotional behaviors - and positive symptoms in schizophrenia
Drugs that increase dopamine will - Answer -increase or produce positive symptoms of
psychosis - delusions and hallucinations
Drugs that decrease dopamine will - Answer -decrease or stop positive symptoms
Antipsychotics that decrease positive symptoms block __________ - Answer -D2
receptor
Cocaine/Meth release dopamine causing _______________ - Answer -psychosis that
is hard to differentiate from positive symptoms of schizophrenia
True/False: No one knows exactly how neurotransmitters and how they relate to
schizophrenia - Answer -True
