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Lecture notes

Antipsychotics pharmacology

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This document contains all the relevant student knowledge pertaining to antipsychotics. This includes: Typical vs atypical Mechanism of action Indication and contraindications Adverse effects

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Document information

  • December 18, 2022
  • 6
  • 2022/2023
  • Lecture notes
  • Caitlin austin
  • All classes

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Two major categories of anti psychotics
A
Typical1stgeneration
chlorpromazine 4 main qualities
Haloperidol Sedation
Flu phenazine Anti Cholinergic
Extrapyramidal
B Atypical 2nd generation Hypertensive
Clozapine
Risperidone
Onlazapine
Quetiapine

MOA
Mostly via blockade of dopamine receptors althoug
they may also block receptors for histamine S HT
serotonin and acetylcholine
Antipsychotics tend to mainly inhibit Da receptors

When 1st administered dopaminergic neuron activity T
but over time around 3 weeks this
activity I The drugs
take several weeks to work



NB Neuroepileptic
malignant syndrome Rare Occurs with a

Certain genetic variant of the Da receptor It can cause

, Rigidity Tachycardia
Delirium Sweating
Fluctuating g p T CK
Extrapyramidal effects

Treat withdraw
drug and give a dopamine agonist
E Mirapex Pramipexole
g

Lithium
Mood stabalizer often used in bi polar It has been
shown to change the inward and outward currents of
It acts to keep glutamate levels
glutamate receptors
between cells at a stable level t mania
glutamate
I
glutamate depression

Prescribing
Tablet or liquid form as Priadel Camcol it It is
available as lithium carbonate or citrate these are not
dose equivalent


Dose Priadel
achieve optimal lithium
SO 0.4 1.2g daily
kg
0.8 1 0mmol L

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