NBME 12 - Latest 2023/2024

NBME 12 - Latest 2023/2024 Leiomyoma -- Progressive asymmetric weakness of hands/feet? -- ALS; Xeroderma Pigmentosum -- Defect in Nucleotide excision repair; Prevents repair of pyrimidine dimers due to UV radiation Lesion of Hippocampus -- Inability to form new memories Infliximab, Adalimumab, Certolizumab -- Monoclonal antibody against TNF-a; Ribavirin -- Chronic HCV; Inibits synthesis of guanine nucleotides by inhibiting inosine monophosphate dehydrogenase Early Developmental Milestones (3-5 y/o) (DFL) -- Drive (tricycle), Drawings (copies lines or circle), Dexterity (hops on 1 foot by 4 y/o); Freedom, Friends; Language (1000 words), Legends (can tell stories) Sulfasalazine -- Sulfapyridine + 5 aminosalicyclic acid; UC and Crohn disease Neissera gonorrhea? treatment -- Patient can present with painful swelling in joints; Ceftriaxone LLQ pain + fever + leukocytosis -- Diverticulitis; Associated w/ low-fiber diets Vinblastine, Vincristine -- Prevent mitotic spindle formation (M phase arrest) AE: Neurotoxicity PBS of Hereditary Sphereocytosis -- Ehrlichiosis? Treatment -- Vector is tick; MONOCYTES w/ morulae; Treatment: Doxycycline Anaplasmosis? Treatment -- Vector is tick; GRANULOCYTES w/ morulae; Treatment: Doxycyline