CSO Chemotherapies questions with complete solutions

Bexarotene/Targretin correct answer: - Intrxn: grapefruit juice; limit vit A <1500 IU/day to avoid additive toxicity - SFX: elevated blood lipids Axitinib/Inlyta correct answer: Avoid grapefruit juice Bortezomib/Velcade correct answer: - Intrxn: green tea - SFX: fatigue, generalized weakness, peripheral neuropathy, n/v, D/C, decr. app, low platelets, anemia Capecitabine/Xeloda correct answer: Antimetabolite - SFX: n/v, D, high bili, farigue - Considerations: B6 (50-100 mg 2-3 times/d) to help w/HFS Cisplatin/Platinol correct answer: Alkylating Agent - SFX: n/v (severe), metallic taste changes, SIADH, renal tox., low Mg - Considerations: hydration to prevent nephrotoxicity; monitor renal fxn and lytes (Mg, Ca, Na, K) Erlotinib/Tarceva correct answer: - Intrxn: grapefruit juice - SFX: n/v, D, decr. app, fatigue, SOB, cough, rash Mercaptopurine/6-MP or purinethol correct answer: Antimetabolite SFX: n/v, mucositis, diarrhea Intrxn: avoid dairy around time of taking drug Methotrexate correct answer: Antimetabolite - SFX: N (severe), mucositis (severe), oral/GI ulcerations, renal toxicity