LAT Test Questions with Correct Solutions| Rated A+

When developing a new drug what is the correct order of testing? - In Vitro preclinical and clinical How often does the animal welfare regulations require the IACUC to review and do inspections of the facilities? - At least every six months Which of the agencies regulates disinfectants and sterilizers used on hard surfaces? - United States and environmental protection Agency What type of floor plan is designed so each room has exit doors to a Dirty corridor that wraps around the periphery of the floor plan? - Three-corridor What is a biofilm? - Microrganism build-up on tank wall What substance can be added to an aquatic system to raise pH? - Sodium bicarbonate Which parameter is a measure of both calcium and magnesium ions in water? - Total hardness AWR (enforced by USDA) require IACUC have how many members? - A tleast 3. Chairperson,vet,and a member not associated with inst. PHS policy requires how many IACUC members? - At least 5. Chairperson,vet,scientist,nonscientist, and community member. Nonfederal research facilities must register with USDA if species are covered by? - AWA. Updates every 3 yrs. signed by IO. Inst. housing USDA Covered animals must submit a report how often to the USDA? - Annually (PHS) Public health service - Publishes the policy on the humane care and use of laboratory animals. (AAALAC) Association for Assessment and Accreditation of Laboratory Animal Care International - Provides peer evaluation of animal care and use programs (AWR) Animal welfare regulation - Describes what a facility must do to comply with the AWA (FDA) Food and drug administration - Requires compliance with the good laboratory practices (GLPs) (USDA) U.S. Department of agriculture - Registers institutions using species covered by animal welfare act What two federal agencies require compliance with the GLPs? - (EPA)environmental protection agency and (FDA) food and drug admin. How often must insitutions update registration with USDA if using AWA species? - Every 3 yrs What agency enforces the PHS policy? - (OLAW) Office of laboratory animal welfare What document is signed by IO and is filed to commit the institution to compliance with the PHS policy? - Animal welfare assurance What animals are covered under the PHS policy? - ALL vertebrates USDA covered animals submit a report to the USDA how often? - Annually USDA covered species may only be approved for how long? - 1 year USDA vet med officers (VMO) conduct unannouced ispections how often? - Atleast annually IACUCs are mandated by what? - Federal mandate What is a quality assurance unit responsible for ensuring compliance with? - GLP Which organization uses the GUIDE as one of its standards for accreditation of Lab animal programs? - AAALAC Most aquatic tanks are made of what plastic? - Polycarbonate and polysulfone Water conductivity is? - Measure of amount of dissolved salts and minerals Water hardness is the measure of what? - Specific ions dissolved in the water What two ions are main ones measured by hardness? - Calcium and magnesium What percentage of oxygen by volume is in water? - Less than 1% If too many ions in the water, water will flow how in accordance to the animal? - Flow out of the animal If there are too few ions in the water, the water will flow how in accordance to the animal? - Flow into the animal What are the three types of vessels? - Arteries, veins, and capillaries The contraction phase of the heart is called? - Systole The relaxation phase is called? - Diastole Nodes are found in 5 areas and many tissues: - Neck(cervical), rear leg(popliteal), armpit(axilary), groin area(inguinal) What acts like an insulator and makes the nerve appear white? - Myelin Which organization uses the guide as one of its standards for accreditation of lab animal programs? - Association for assessment and accreditation of lab animal care (AALAC) What hormone lowers the blood glucose level? - Insulin If animal was used in experiments, teaching, tests causing pain or distress for which appropiate anasthetic or tranquilizing drugs were used, what USDA pain category would it be? - "D"