Pharmacology Ch. 31 Opioid Analgesics & Antagonists 2023/2024

Pharmacology Ch. 31 Opioid Analgesics & Antagonistswhat are the major therapeutic uses of opioid drugs? - correct answer analgesics antitussives antidiarrheal what are partial opioid agonists? what is the prototype of a strong analgesic or full agonist? - correct answer -partials exert less analgesia than morphine -morphine is the prototype which drugs undergo extensive 1st pass metabolism? - correct answer morphine hydromorphone oxymorphone what is an opiate? - correct answer drug derived from alkaloids of opium poppy what is an opioid? - correct answer class of drugs that include opiates, opiopeptins, and all synthetic/semisynthetic drugs that mimic the actions of the opiates what is the distribution of opioids in body tissue? can they cross the placenta? - correct answer -widely distributed to body tissues -yes they cross placenta and exert effects on fetus. can lead to respiratory depression and physical dependence in neonates what is the general metabolism of opioids? - correct answer -hepatic enzymes (to glucuronide conjugates) then eliminated in kidney