Summary
Summary YR 2 CONTENT
- Institution
- University Of Sunderland (UoS)
Summary of 3 pages for the course Foundations Of Biomedical, Behavioural And Social Sciences For Medicine 2020/21 at UoS (YR 2 CONTENT)
[Show more]
Seller
Follow
Content preview
Diseases of the immune system 2Autoimmunity= pathological state where there has been a breach in tolerance to self and
the immune system attacks one’s own tissue
Response to self =normal damaging effector response=not normal
Chronic autoimmune disease=positive feedback loop
Inflammation- presentation of self peptides-inability to clear self antigen-damage-
broadening of the immune response-presentation of more self peptide=more cells recruited
Development of autoimmunity:
Genetic: MHC,AIRE,FOXP3
Environmental: smoking,chemicals,gas,UV,infection
Occurrence runs in families
Susceptibility can be increased by specific genes which:
Disrupt tolerance, apoptosis
Promote inflammation,cell activation
Monogenic-one predominant genetic risk
Complex-multiple risks- interaction between genetic and environmental
MHC genes
Polygenic- Locus of a gene contains a set of several different MHC I and II so an individual
expresses several MHC I and II with different peptide binding specificities
Polymorphic-different alleles for each gene
These affect the TCR and antigen/MCH complex binding and antigen and MHC
Expression of a type of HLA can be contributing factor to autoimmunity
Why are females more susceptible to
autoimmunity:
Stronger humeral response
Higher levels of antibodies
Oestrogen can enhance B cell responses
High levels inhibit inflammation
Testosterone- negatively regulates BAFF gene-
survival factor for B cells in the spleen
Overcoming peripheral tolerance: adjuvant
effect-injection of tissue extracts with microbial products (danger signals)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller manalmalik4. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £7.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
59325 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now