Lecture notes
Lecture notes ligand-gated ion channel
- Module
- Pharmacology
- Institution
- University Of Sunderland (UoS)
ligand-gated ion channel superfamily Notes all those notes should prepare you for the written exam, good luck:)
[Show more]
Seller
Follow
Content preview
exam Question :Ligand-gated on channel
& Describe
* features/characteristics of Ligand-gatedion channel superfamily
↳ of conformational
binding ligand (neuro transmitter) =>
change in receptor protein =>
opening
of ion-permeable pore > flow of permeant ions
into/out of cell down their electrochemical gradient.
↳ in flow
through activated channel
= > modulation of cellular function.
↳ LGIs involved in wide range biological functions.
synaptic franission sh neural communications
e
g
.
cell excitation , muscle contraction s intracellular signalling.
question Describe
exam :
* basit for subclassification of
ligand-gated in channel families
↳
based on effect on membrane potential st cellular electrical
induced Channel
activity by ion flow
through open
* Excitatory ,
cation-selective LGIs => nAChR ,
S-HTzR
ionotropic glutamate (NMDA ,
AMPA & Kainate) receptors
& P2X receptors·
Mediate influx of cation= > membrane depolarisation
* inhibitory ,
anion-selective LGI +=> GABAAR$
glycine receptors exam question : Describe
↳ characteristic feature of major
- Mediate influx of anion
= > Membrane
hyperpolarisation .
Key
channel families
Ligand-gated ion
I
cys-loop Receptor family
-
pentameric :
composed of S subunits
- nAChR , S-HTsR , GABAAR ,
glycine receptors
-
Conotropic Glutamate Receptor family
Tetrameric
- composed : of 4 submit
-
NMDA ,
AMPA & Kainate receptor
③ 2X Receptor family
-
Trimeric :
composed of 3 subunits
-
P2x1 ,
P2X2 , P2X3 , P2X4 ,
P2X5 & P2X7
receptors
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller ralromaimi. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £6.96. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
81989 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now