SBB study guide with 100% correct answers 2024

What enzyme may be useful in distinguishing anti-Ge2 from anti-Ge3? - correct answer Papain (Anti-Ge2 will not react) The beta 1-3 linkage between galactose and N-actylglucosamine is found in: - correct answer Secretions Which of the following represents the Type II chain? - correct answer Beta 1-4 linkage between galactose and N acetyl glucosamine Rank the order of decreasing H concentration on RBCs - correct answer 0A2BA2BA1A1B All of the following are genotypes for the A1 phenotype except: 1. A1/A1 2. A1/A2 3. A2/B 4. A1/O - correct answer A2/B The ABO genes are located on which chromosome? - correct answer 9 Which glycosyltransferase is needed before A and B antigens are formed? - correct answer L-fucosyltransferase What is the typical reaction of the A3 subgroup? - correct answer mixed field reaction with Anti-A and Anti-A,B What is the typical reaction of the Ael subgroup? - correct answer Positive reaction with anti-H What clinical condition may yield positive reactions with Anti-A, negative with Anti-B, negative with A1 and B cells. - correct answer Hypogammaglobulinemia What differentiates a Bombay anti-H from an anti-H cold agglutin? - correct answer Reactivity at body temperature The is antigen is associated with linear carbohydrate chains? - correct answer i antigen The following reactions are found on a 35 yr old male. Anti-A 4+, Anti-B 0, Anti-A,B-4+, A1 cells 3+, B cells 4+, O cells 3+. How could these be explained? - correct answer Anti-M in plasma Anti-IH would react best with which RBC? - correct answer O The acquired B phenomenon is only found in which ABO group? - correct answer A Which of the following is true about the A2 subgroup? 1. 1-8% of persons will product anti-A1 2. Anti-A1 does not react with A2 RBCs 3. Anti-A2 is formed 4. Two of the above - correct answer Two of the above (1-8% of persons will product anti-A1 and Anti-A1 does not react with A2 RBC ) Anti-Lu3 is associated with: - correct answer Recessive type Lu(a-b-) The dominant Lu(a-b-) type is associated with what gene? - correct answer In(Lu) What substance could be used to rule out anti-E in the presence of anti-Lub? - correct answer DTT Which pair of alleles is out of place? 1. Lu8/Lu14 2. Lu8/Lu10 3.Lu6/Lu9 4. Aua/Aub - correct answer Lu8/Lu10 Persons who are group B are more common among which population? - correct answer Black/Asian Red cells that lack glycophrin A also lack: - correct answer Ena antigens Anti-ENKT reacts with which RBCs? - correct answer ENaFS What is a lectin? - correct answer Seed extracts that agglutinate human cells with moderate specificity All of the following are representative of Lewis antibodies, except? 1. They can be neutralized by Lewis substance 2. They occur frequently in pregnant women 3. They are destroyed by enzymes 4. They are enhanced by enzymes - correct answer They are destroyed by enzymes Why can anti-H sometimes be fund in A2B persons? - correct answer The specific immunodominant sugar blocks the presence of H antigen Why is determenantion of Rh status crucial for obstetric patients? - correct answer All Rh negative mothers are possible candidates for Rhogam An adult who inherits Le,Se and H will type as: - correct answer Le(a-b+) What immunodominant sugar is responsible for B specificity? - correct answer D galactose Red cells that phenotype as Le(a-b-) will convert to Le(a+b-) when incubated with plasma from an adult containing? - correct answer Le(a+) substance What genotype does hh represent? - correct answer Bombay The Rh gene is located on chromosome? - correct answer 1 Why are Lewis antibodies no implicated in hemolytic disease of the newborn? - correct answer Lewis antigens are poorly developed at birth What substances will be present in the saliva of a person with the LeLe HH SeSe AA genotype? - correct answer A, H, Lea, Leb How is Le(b) substance formed? - correct answer L fucose is added to the subterminal N acetylglucosamine of type 1H substance A person with the Oh phenotype can only receive RBC from: - correct answer Only Oh persons What amino acid is specific for the S antigen? - correct answer Methionine Which of the following is true regarding the U antigen? - correct answer Most U negative RBC are also S-s- Why is it imperative that homozygous cells be employed when ruling out Kidd antibodies? - correct answer Anti-Jka may appear compatible with heterozygous cells Anti-I is associated with what infectious agent? - correct answer Mycoplasma pneumonia What Kidd antibody wil react with all panel cess, but not the autocontrol? - correct answer Anti-Jk3 All of the following are characterists of anti-Fya and anti-Fyb, EXCEPT: 1. can cause HDFN 2. Reacts best in AHG 3. enhanced with enzymes 4. IgG - correct answer Enhanced with enzymes This antibody typically causes RBC to exhibit a refractile shiny appearance and mixed field reaction at AHG, and can be neutralized by most human urine? - correct answer Anti-Sda What solution can denature Bennet-Goodspeed antigens? - correct answer Cholorquine diphosphate Persons with the McLeod phenotype do not express this marker. - correct answer Kx DTT will destroy antigens from which blood group? - correct answer Kell Chronic granulomatous disease (CGD) is associated with what phenotype? - correct answer McLeod What P antigens are present in the p phenotype? - correct answer none What antigens are present in the P1 phenotype? - correct answer P1, P, Pk What phenotype can produce anti-PP1Pk? - correct answer p This antigen is found more on cord cells than on adult cells? - correct answer i Which antibody is associated with PCH? - correct answer Anti-P Which of the following is true regarding the Diego antigens? - correct answer They are not destroyed by Enzymes Which of the following is false regarding anti-Wrb? 1. They are mostly IgG 2. Implicated in HTR 3. Mostly IgM 4. Implicated in HDN - correct answer Mostly IgM Which of the following is true regarding the Yt blood group system? 1. Antigens are destroyed by common enzymes 2. Not denatured by DTT 3. Antibodies are usually IgM 4. Antibodies are usually IgG - correct answer Antibodies are usually IgG Which of the following is true regarding the Xg blood group system? 1. Antibodies are enhanced by enzymes 2. Antibodies are IgM 3. Antibodies react in the AHG phase 4. Xga is clinically significant - correct answer Antibodies react in the AHG phase John Milton Hagen (JMH) antigens are dstroyed by proteolytic enzymes? True or False - correct answer True Cromer antibodies are usually: - correct answer IgG Which of the following is false regarding the Knops blood group system? 1. Antigens are resistant to ficin 2. Antibodies are not clinically significant 3. Antigens are on a complement glycoprotein 4. Antigens are destroyed by ficin - correct answer Antigens are destroyed by ficin Which of the following is true regarding the Colton system? 1. Antibodies are usually IgG 2. Not implicated in HTR 3. Antibodies are usually IgM 4. Not implicated in HDN - correct answer Antibodies are usually IgG What is unique about the Chido/Rodgers system? - correct answer Antibodies are neutralized by antigen positive plasma When is anti-SC3 produced in patients? - correct answer If pt is Scianna null phenotype Ina and Inb are destroyed by: 1. Papain 2. Ficin 3. DTT 4. All of the above - correct answer All of the above (papain, ficin, DTT) Which of the Gerbich phenotype produces anti-Ge2? - correct answer Ge:-2,3,4 How would and R1R1 person translate to Rosenfield terminology in the Rh system? - correct answer Rh: 1,2,-3,-4,5 (FR= DCe/DCe) Anti-C is found in an O negative patient going to surgery. What type of blood should you prepare for transfusion? - correct answer rr type O What antibody might you suspect in a patient of Polynesian heritage? - correct answer Anti-Jk3 A patient on antithymocyte globulin therapy may produce antibodies that mimic what specificity? - correct answer Lutheran Which of the following Fisher-Race phenotypes compares with Rosenfield's Rh:1,-2,3,4,-5 - correct answer R2R2 (DcE/DcE) A patient has formed anti-KL. What patient population's RBCs might be compatible? - correct answer McLeod persons Anti-rhi can react with what phenotype? - correct answer R1R2 Which cells would be devoid of glycophroin B? - correct answer Mk/Mk What is unique about the In(JK) gene? - correct answer Resistant to lysis in 2M urea This Fy antigen is not altered by ficin or papain? - correct answer Fy3 A patient whose red cells types as D+C-E-c-e- Evans + could form what antibody? - correct answer Anti-Hro What does rh' represent in the Weiner nomenclature? - correct answer C Which of the following may produce anti-Rh29? - correct answer Rh null person Cellano would have strong expression in all of the following EXCEPT: a. K-k+ Kp(a+b+) b. K+k+ Kp(a-b+) c. K-k+ Kp(a-b+) d. K-k+ Kp(a+b-) - correct answer K-k+Kp(a+b-) (due to Kpa effect) What may be the best source of Lewis null cells? - correct answer Cord blood What antibody may be made from Ko indivduals? - correct answer Anti-Ku The cde/cde genotype has the least amount of what antigen? - correct answer LW Which of the following represents a null phenotype? 1. INAB 2. Fy5 3. SC1 4. Hy - correct answer INAB What is true concerning Rh null cells? 1. They are negative for Jk3 2. They are negative for Jk5 3. They are negative for S 4. All of the above - correct answer They are negative for Jk5 What Rh antibody is typically discribed as alloanti-e like? - correct answer Anti-hrB Which RH antigen is high frequency? 1. Bea 2. Evans 3. hrH 4. HrB - correct answer HrB Which of the following represent decreasing immunogenicity for major Rh antigens? - correct answer DcECe Which MNS antigen is representative of a anti-Lepore hybrid? - correct answer Henshaw Ficin treatment would be helpful in which of the following? 1. Anti-M 2. Anti-Doa 3. Anti-Lu14 4. Anti-Ch - correct answer Anti-Doa Anti-N' will react with what cells? - correct answer N+,N= What can be said about the dominant type Lu(a-b-) person who inherits two normal Lub genes? - correct answer Anti-Lub can be adsorbed and eluted from their red blood cells What antigens are denatured upon performing and elution with glycine EDTA? - correct answer Kell and Era This antibody is in the MNS group and is reactive with HUT+ RBCs. - correct answer Mia Treating RBCs with this substance could render them Dombrock neg. - correct answer DTT This Rh antigen is a low incidence antigen associated with partial D phenotype DFR? - correct answer FPTT This high frequency antigen is antithetical to Lu9? - correct answer Lu6 The high frequency antigen Santini(Kell system) in antithetical to? - correct answer Callais The Me antigen is expressed on ______ and part of the ______ system? - correct answer GPB/MNS This phenotype expresses Gya, Hy, and Joa? - correct answer DOYA-neg A 56 yr old male who is type O received a stem cell transplant from an allogenic A donor. At day 128 post transplant the recipients isoagglutinins are no longer demonstrable. What type of plasma should the patient receive? - correct answer A What antibody is suspected when all 12 panel cells are reactive at AHG phase and reactions are unaffected by enzymes, DTT, and AET? - correct answer Antibody against Gill A patient with a phenotype K-k+Kp(a+b-) would have a weakened: - correct answer k antigen