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Vasopressin in esophageal varices - Reduces portal hypertension (ran at high doses of 0.4-1) -Watch with CAD patients!! What is the most common cause of acute hepatic failure? - DILI (drug-induced)- most commonly by acetaminophen Why would you watch for sepsis in a hepatic failure patient? - Bacteria can enter the blood stream from ascites/GI tract What is one of the key clinical differences between acute and chronic hepatic failure? - Acute there will not be portal hypertension Labs indicative of acute hepatic failure: 1.) Bilirubin will be ___ x normal range along with jaundice 2.) Aminotransferase ___ x normal range ^ Presence of these = poor prognosis with 10-50% mortality without transplant - 1.) 2 x 2.) 3 x In event of acetaminophen overdose the reversal agent is - N Acetylcysteine (Mucomyst) What happens to the liver in chronic hepatic failure? - -Hepatic parenchymal cells destroyed, replaced with fibrotic tissue -Constriction of blood flow leads to portal hypertensionWhere typically will jaundice be observed first? - Sclera Why do esophageal varices develop?(have elevated coag times with hepatic failure) - Portal hypertension; up to 30% mortality if bleed Octreotide - Used for bleeding/hemostasis What is the purpose of the TIPS procedure? - B. Relieve portal venous pressure Which of the following signs would the patient report as left shoulder pain that is indicative of ruptured spleen? - Kehr's sign (referred l shoulder pain) Why might you place a hypotensive liver patient with ascites on their side? - Relieve pressure on the aorta from the ascites and increase venous return to the heart Neuro Encephalopathy: Asterixis - Involuntary flapping of hands

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CCRN: Liver Failure
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CCRN: Liver Failure

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CCRN: Liver Failure
Vasopressin in esophageal varices - Reduces portal hypertension (ran at high doses of 0.4-1)

-Watch with CAD patients!!



What is the most common cause of acute hepatic failure? - DILI (drug-induced)- most commonly
by acetaminophen



Why would you watch for sepsis in a hepatic failure patient? - Bacteria can enter the blood stream
from ascites/GI tract



What is one of the key clinical differences between acute and chronic hepatic failure? - Acute
there will not be portal hypertension

Labs indicative of acute hepatic failure:

1.) Bilirubin will be ___ x normal range along with jaundice

2.) Aminotransferase ___ x normal range

^ Presence of these = poor prognosis with 10-50% mortality without transplant - 1.) 2 x

2.) 3 x



In event of acetaminophen overdose the reversal agent is - N Acetylcysteine (Mucomyst)



What happens to the liver in chronic hepatic failure? - -Hepatic parenchymal

cells destroyed,

replaced with fibrotic

tissue

-Constriction of blood

flow leads to portal

hypertension

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Institution
CCRN: Liver Failure
Module
CCRN: Liver Failure

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