DOAC (Direct oral anticoagulants) Test Bundle

DOACs: Meds DOACs: Newest class of anti-coags -Direct Thrombin Inhibitor 1. DabigaTran - Factor Xa inhibitors 1. ApiXaban (Eliquis) 2. BetriXaban (Bevyxxa) 3. EdoXaban (Savaysa) 4. RivaroXaban (Xarelto)

Limitations of warfarin - Answer Requires routine INR monitoring Frequent dose adjustments Has many interactions Delayed onset - often requiring concomitant parenteral anticoagulant Benefits of warfarin - Answer Established monitoring assay (can establish if patient is under or over coa...

DOACs that are factor Xa inhibitors - Answer Rivaroxaban Apixaban Edoxaban DOAC that is a direct thrombin inhibitor - Answer Dabigatran What indication do all DOACs share? - Answer Reduce risk of stroke in nonvalvular atrial fibrillation Dabigatran Indications - Answer Reduce risk...

MOA - Answer Directly blocks Xa and thrombin (works immediately) Drug: Dabigatran (direct thrombin inhibitor) - Answer Pradaxa Drug: Rivaroxaban (direct factor Xa inhibitor) - Answer Xarelto Drug: Apixaban (direct factor Xa inhibitor) - Answer Eliquis Drug: Edoxaban (direct facto...

MOA of DOACs - Answer direct factor Xa inhibitor MOA of dabigatran - Answer direct thrombin inhibitor dosing of dabigatran for VTE - Answer usual: 150 mg PO BID after 5-10 days of injectable anticoagulant renal: contraindicated if CrCl <30 ml/min monitoring for dabigatran - Ans...

Based on the readings, which DOAC has the shortest half-life yet is dosed once daily? A. Apixaban B. Rivaroxaban C. Dabigatran C All the DOACs have a short onset of action; however, which two require "bridging" with a parenteral anticoagulant for the treatment of DVT/PE? A. Dabigatran an...

What are DOACs used for? - Answer - VTE treatment and prophylaxis - stroke prevention (non-valvular a fib) - CAD and PAD What advantages does DOACs have over warfarin? - Answer - fixed dosing - predictable - quick onset - minimal drug-food/drug interactions - less monitoring -wide TR ...

Direct Oral Anticoagulants are a drug class that....? - Answer Directly binds to and inhibits clotting factors IIa (thrombin) or Xa What is unique about Dabigatran compared to the other 4 DOACs? - Answer Only direct thrombin inhibitor Which DOACs cannot be crushed? - Answer -Dabigatra...

T/F Anticoagulants dissolve/breakdown clots - Answer false! only prevent clots from forming and keep existing clots from getting larger Anticoagulant uses - Answer ACS prevention of cardioembolic stroke prevention/treatment of VTE (DVT and/or PE) Warfarin inhibits which factors? - An...

Following Up on DOACs: Checklist - Answer - Compliance: check adherence and educate on importance - Thromboembolism: check for recurrence of clotting - Bleeding: educate on bleed prevention and management - Other ADRs: no many - Co-Medications: check for DDIs Blood Sampling: renal & hepatic F...

What are the new oral anticoagulants? - Answer target specific oral anticoagulants: TSOACs new oral anticoagulants: NOACs direct oral anticoagulants: DOACs what are disadvantages of vitamin k antagonists - Answer requires bridging due to delay of onset of action narrow therapeutic index ...