Other
NR565/NR565 WEEK 6: CHAPTER 24: Drugs used in treating infectious disease
- Institution
- Chamberlain College Of Nursng
NR565/NR565 WEEK 6: CHAPTER 24: Drugs used in treating infectious disease
[Show more]
Content preview
WEEK 6: CHAPTER 24: Drugs used in treating infectious diseaseANTIMYCOBACTERIALS
Mycobacteria- among the most difficult to cure (e.g. tuberculosis [TB])
o They grow slowly and are relatively resistant to drugs that are largely dependent on how rapidly
cells are dividing
o Have a lipid-rich cell wall relatively impermeable to many drugs
o Are usually intracellular and inaccessible to drugs that does not have good intracellular
penetration
o Have the ability to go into a dormant state
o Easily develop resistance to any single drugs
o Pregnancy categories:
Isoniazid: Pregnancy category A
Streptomycin: Pregnancy category D
The rest: Pregnancy category C
Fetal death- d/t TB: isoniazid + rifampin + ethambutol for TB tx if pregnant and
if drug resistance is a possibility.
Spectrum of coverage for various organisms/Pharmacodynamics
o Isoniazid - most active drug for tx of TB
Bactericidal- against susceptible mycobacteria (intracellular and extracellular
organisms)
Interferes with lipid and nucleic acid biosynthesis in growing organisms.
Isoniazid and ethambutol- inhibits synthesis of mycolic acid (important
constituents for mycobacteria cell walls and are not found in mammalian cells).
o Rifamycins – rifampicin, rifabutin, rifapentine
Bactericidal- against susceptible mycobacteria
Bind to the beta subunit of mycobacteria DNA-dependent RNA polymerase and
inhibit RNA synthesis -> destruction of both multiplying and inactive bacilli.
Readily penetrate most tissues and can kill bacteria that are poorly accessible to
many drugs.
Rifampin and rifabutin: N. gonorrhoeae, staphylococci, streptococci,
Mycobacterium leprae, MAC, and H. influenzae type B.
Rifampin-resistance develop rapidly when used as monotherapy- should be
combined with another active abx for tx of established infections.
o Ethambutol
Bacteriostatic- against susceptible mycobacteria (M. tuberculosis, M. avium, M.
kansasii)
Inhibits synthesis of arabinogalactan (an essential component of mycobacteria
cells walls).
Arrests cell multiplication -> cell death
Enhances the activity of lipophilic drugs (rifampin and ofloxacin) that cross the
mycobacteria cell wall primarily in lipid portions of this cell wall.
o Pyrazinamide- an analogue of nicotinamide
Bactericidal – against M. tuberculosis in an acidic environment (pH <5.6).
Useful in tx of TB
, Exhibits good activity within macrophages and plays a key role in killing
intracellular organisms.
Shortening therapy and preventing relapses
Exact action is UNKNOWN.
o Streptomycin – aminoglycoside, used now almost exclusively to treat M. tuberculosis
infections.
Bactericidal in alkaline extracellular environment
Added as the 4th drug to the regimen for TB
Sensitive to M. avium and M. kansasii; resistant to all mycobacterium
Irreversible inhibitor of protein synthesis.
Penetrates cells poorly
o Ethionamide- similar binding site and mechanism of action as isoniazid.
Ultimately blocks the synthesis of mycolic acids.
Bacteriostatic – M. tuberculosis
Can inhibit some other Mycobacterium species.
o Capreomycin – peptide abx
Bactericidal to susceptible mycobacteria.
Inhibits RNA synthesis -> decreasing replication of M. tuberculosis.
Resistance easily develops when given as monotherapy (should be given as part
of multidrug regimen)
o Bedaquiline – unique antimycobacterial, approved by FDA in 2012
For tx of multidrug resistant TB
Inhibits mycobacterial adenosine triphosphate (ATP) synthesis
Active against replicating and dormant mycobacteria
Black-box warning: increased mortality as compared with a placebo tx group.
Only to be used when an effective tx regimen cannot otherwise be provided.
o Para-aminosalicylic acid- structurally similar to PABA and sulfonamides
Folate synthesis antagonist
Active almost exclusive against M. tuberculosis.
Bacteriostatic
Not used frequently – primary resistance is common, and other drugs are better
tolerated and less expensive.
Pharmacokinetics
o Oral antimycobacterials are rapidly and well absorbed in GI tract after PO administration.
o Isoniazid- 90% bioavailable but should be taken on an empty stomach
Readily diffuses into all body fluids including CSF (90% of serum levels), pleural,
and ascitic fluids
Readily diffuses into tissues, organs, saliva, sputum, and feces
Crosses placenta and breastmilk
Metabolism is extensive and highly variable and dependent on acetylator status.
Primarily acetylated by the liver
50% of both blacks and whites are slow acetylators
Alaskan and Asians- majority are rapid acetylators
Rate of acetylator does not affect effectiveness but may increase risk for
toxic reactions with slow acetylators.
Excreted in the urine- metabolites, and unchanged drug
, Elimination is largely dependent on renal function
o Rifamycins and ethambutol penetrate and concentrate in most body fluids.
Adequate CSF penetration occurs only in the presence of inflamed meninges.
Potent inducers of liver metabolism
Rifampin and rifapentine- metabolized in the liver by deacetylation.
Metabolites are active against M. tuberculosis.
t1/2 life decreases with repeated administration
excreted primarily in the bile -> enterohepatic recirculation -> feces, urine (small
amount)
hepatic insufficiency and age slightly affect metabolism of rifabutin only.
Renal insufficiency- reduced drug distribution and faster drug elimination ->
decreased drug concentrations.
Food slow the rate of absorption of rifamycins but not the extent of absorption
(may be taken with or without food)
o Pyrazinamide- widely distributed in body tissues and fluids including the liver and lung.
Reaches high concentrations in CSF
Crosses the placenta and enter breastmilk in small amounts
Poor CSF penetration (good penetration if meninges are inflamed)
70% excreted in urine by glomerular filtration
Hydrolyzed by the liver to as a metabolite
Prolonged t1/2 - significant on impaired hepatic and renal functions.
o Ethionomide- widely distributed to body tissues and fluids- CSF and serum
concentrations are equal
35% metabolized by the liver
Majority of the drug excreted in the urine as inactive metabolites
o Ethambutol- mainly excreted as unchanged drug in the urine.
20% metabolized by the liver
Marked accumulation may occur in renal failure
Pharmacotherapeutics
o Isoniazid- careful monitoring for hepatotoxicity (ETOH drinkers, chronic liver disease,
severe renal function, >35y/o, drug abuse, pregnant, immediately postpartum)
Peripheral neuropathy, neurotoxicities may occur
Special caution: patients with preexisting peripheral neuropathy,
pregnancy, and (+) HIV.
o Ethambutol, streptomycin, capreomycin
Cautious use for patient with renal impairment
Dose adjustments may be required
o HEPATOTOXIC: R-ifamycins, I-soniazid, P-yrazinamide, E-thionamide (RIPE)
o Thrombocytopenia and anemia: rifampin and isoniazid
o Gouty arthritis attacks: ethambutol and pyrazinamide
o Visual disturbances, irreversible blindness- ethambutol (cautious use with eye disorders
such as diabetic retinopathy, cataracts, optic neuritis)
o CYP enzyme:
Rifamycins- potent inducers of liver metabolism
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Joy100. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67096 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now
