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 What is pathophysiology? o the study of abnormalities in physiologic functioning of living beings. It is studies in terms of common, or classic, presentations of disorders.  Stress response o body’s attempt to try to restore the balance; is helpful but can become damaging when repeatedly activated or does not cease.  Flight or flight o The alarm stage; because it provides a surge of energy and physical alterations to either evade or confront danger. (when the hypothalamus senses a need to activate the GAS in response to a stimulus, a stressors placing the balance of homeostasis at risk)  Epidemiology and the treatment of disease o the study of health events and patterns of disease involving aggregates of people, their distribution, and associated causative factors in a defined population  Hans Selye’s General Adaptation Syndrome o Alarm (fight or flight), resistance (adaptation; move beyond the alarm stage), exhaustion (no longer able to effect a return to homeostasis) stages  What is homeostasis? Allostasis? o Maintaining internal conditions in a stable state by keeping things relatively the same, or balanced o ability to successfully adapt to challenges to maintain survival and well-being (i.e. BP, HR, glucose levels) o Allostatic overload- when adaptation mechanisms are inadequate or total amount of allostatic load is excessive; homeostasis cannot be obtained  Osmosis vs passive transport vs filtration o Movement of water across a semipermeable membrane to equalize the particle concentration of the fluid on both sides of the membrane. o Called facilitated diffusion; particles move through the cell membrane from an area of higher concentration to an area of low concentration w/o the use of energy o Particles move through the cell membrane from an area of low concentration to high concentration; requires the use of energy; ATP  Edema o Excess of fluid in interstitial compartment; may be localized or generalized; stages +1, +2, +3, +4  Osteoporosis o Most common metabolic bone disease in which reduction in bone mass results from bone resorption proceeding at a rate faster than that of new bone formation. (s/s: shortened stature, muscle wasting, back muscle This study source was downloaded by from CourseH on :13:58 GMT -05:00 NUR2603 ESSENTIALS OF PATHOPHYSIOLOGY EXAM 1 REVIEW spasms, difficulty bending over)  Transmission of infections o An unbroken chain of events must occur to allow one human to infect another. o Direct transmission: body fluids-droplet, animal bites/soil, placenta transfer o Indirect transmission: vehicle-borne (infectious agent is transported to the host), vector-borne (mechanical or biological transfer), airborne (with aerosols) o Most effective ways to break the chain of transmission: handwashing  Myasthenia Gravis o Chronic autoimmune disease; affects neuromuscular function of voluntary muscles o Acetylcholine receptor antibodies destroy or block acetylcholine receptors of muscle endplate of the neuromuscular junction. o Manifestations: profound muscle weakness and fatigability o Can lead to respiratory depression from weakness o Mind to head  Osteoarthritis o A common, local degenerative joint disease, associated with aging, characterized by progressive loss of articular cartilage, cartilage calcifies, wear of underlying bone, and by formation of new bone from subchondral bone at joint margins.  Pressure ulcers o Localized areas of cellular necrosis resulting from prolonged pressure between any bony prominence and an external object such as a bed or wheelchair o Prevention: turn Q2HR, keep areas clean and dry o Stages I, II, III, & IV  Histamine o An early mediator of the inflammatory response; causes bronchial constriction and mucus production. o Receptor-blocking agents are widely used in allergic reactions, such as skin reactions and hay fever to suppress the inflammatory actions.  Herpes simplex o Two types: HSV-1: occurs above the waist; lips, mouth, face; HSV-2: infections in the genital area o Vesicles and erythema; crusts before healing; no cure  Endotoxins o Integral part of the cell wall which is released upon cell death and sometimes during cell growth o Can lead to septic shock, intravascular coagulation, and respiratory failure  Herpes zoste

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NUR2603 ESSENTIALS OF PATHOPHYSIOLOGY EXAM 1 REVIEW
NUR2603 Essentials of Pathophysiology Exam 1 Focused Review
 What is pathophysiology? by keeping things relatively
o the study of abnormalities the same, or balanced
in physiologic functioning o ability to successfully adapt
of living beings. It is studies to challenges to maintain
in terms of common, or survival and well-being (i.e.
classic, presentations of BP, HR, glucose levels)
disorders. o Allostatic overload- when
 Stress response adaptation mechanisms are
o body’s attempt to try to inadequate or total amount
restore the balance; is of allostatic load is
helpful but can become excessive; homeostasis
damaging when repeatedly cannot be obtained
activated or does not cease.  Osmosis vs passive transport vs
 Flight or flight filtration
o The alarm stage; because it o Movement of water across a
provides a surge of energy semipermeable membrane
and physical alterations to to equalize the particle
either evade or confront concentration of the fluid
danger. (when the on both sides of the
hypothalamus senses a membrane.
need to activate the GAS in o Called facilitated diffusion;
response to a stimulus, a particles move through the
stressors placing the cell membrane from an area
balance of homeostasis at of higher concentration to
risk) an area of low
 Epidemiology and the treatment of concentration w/o the use
disease of energy
o the study of health events o Particles move through the
and patterns of disease cell membrane from an area
involving aggregates of of low concentration to high
people, their distribution, concentration; requires the
and associated causative use of energy; ATP
factors in a defined  Edema
population o Excess of fluid in interstitial
 Hans Selye’s General Adaptation compartment; may be
Syndrome localized or generalized;
o Alarm (fight or flight), stages +1, +2, +3, +4
resistance (adaptation;  Osteoporosis
move beyond the alarm o Most common metabolic
stage), exhaustion (no bone disease in which
longer able to effect a reduction in bone mass
return to homeostasis) results from bone
stages resorption proceeding at a
rate faster than that of new
 What is homeostasis? Allostasis?
bone formation. (s/s:
o Maintaining internal
shortened stature, muscle
conditions in a stable state
wasting, back muscle




This study source was downloaded by 100000841341657 from CourseHero.com on 04-29-2022 04:13:58 GMT -05:00


https://www.coursehero.com/file/43938798/NUR2603-Exam-1-Focused-Reviewdocx/

, spasms, difficulty bending calcifies, wear of underlying
over) bone, and by formation of
new bone from subchondral
bone at joint margins.


 Transmission of infections  Pressure ulcers
o An unbroken chain of events o Localized areas of cellular
must occur to allow one necrosis resulting from
human to infect another. prolonged pressure
o Direct transmission: body between any bony
prominence and an external
fluids-droplet, animal object such as a bed or
bites/soil, placenta transfer wheelchair
o Indirect transmission: o Prevention: turn Q2HR,
vehicle-borne (infectious keep areas clean and dry
o Stages I, II, III, & IV
agent is transported to the
host), vector-borne  Histamine
o An early mediator of the
(mechanical or biological
inflammatory response;
transfer), airborne (with causes bronchial
aerosols) constriction and mucus
o Most effective ways to break production.
the chain of transmission: o Receptor-blocking agents
handwashing are widely used in allergic
reactions, such as skin
 Myasthenia Gravis
reactions and hay fever to
o Chronic autoimmune
suppress the inflammatory
disease; affects
actions.
neuromuscular function of
voluntary muscles  Herpes simplex
o Acetylcholine receptor o Two types: HSV-1: occurs
antibodies destroy or above the waist; lips, mouth,
block acetylcholine face; HSV-2: infections in the
receptors of muscle end- genital area
plate of the neuromuscular
junction.
o Vesicles and erythema; crusts
o Manifestations: profound before healing; no cure
muscle weakness and  Endotoxins
fatigability o Integral part of the cell wall
o Can lead to respiratory
which is released upon cell
depression from weakness
death and sometimes during
o Mind to head
cell growth
 Osteoarthritis
o Can lead to septic shock,
o A common, local
degenerative joint disease, intravascular coagulation,
associated with aging, and respiratory failure
characterized by  Herpes zoster
progressive loss of articular
cartilage, cartilage



This study source was downloaded by 100000841341657 from CourseHero.com on 04-29-2022 04:13:58 GMT -05:00


https://www.coursehero.com/file/43938798/NUR2603-Exam-1-Focused-Reviewdocx/

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