NURS 660 EXAM 2 questions with complete solutions

Which medication has the SE of losing hair correct answer: Lithium The pt is bipolar, and had a partial response to depakote and now is going to be augmented with an atypical antipsychotic, the effects of atypical antipsychotics in non-psychotic mania may be due to what correct answer: indirect effect on glutamate release via 5H2A antagonism A pt has had some success with his current antidepression medication, has tried many different antidepressants, so you decide to augment with L-methyl-folate. What is the hypothesis behind L methyl Folate boosting the therapeutic efficacy of antidepressants...what is the MOA? correct answer: boosts monamine neurotransmitter function in bipolar disorder You have a pt that has been very depressed and has insomnia problems with concentrations, weight loss and SI. You start them on an AD and his symptoms have abated, however which of the following symptoms is the most likely to be residual following the successful tx of other symptoms? correct answer: insomnia Which class of antidepressant have a lower incidence of sexual SE? What medication is used in the tx of BP/mania and is used in prophylaxis as well as antidepressant augmentation? Which medication is this? correct answer: Wellbutrin What medication is a very potent CYP450 inhibitor and can dangerously elevate lamotrigine? correct answer: Valproate Which class of antidepressant has the worst discontinuation syndrome? correct answer: Cymbalta You have a female pt complaining of lactating and is not pregnant w/ no children. She has been taking risperidone. Which medication would you avoid if you were to switch her to another med?" correct answer: Paliperidone A pt is on Prozac and it has stopped working. Patient has been on many other antidepressants and wants to try an MAOI now. How long do you need to stop Prozac before starting MAOI? correct answer: 5-6 weeks What neurotransmitter are affected by TCAs? correct answer: Serotonin, dopamine, norepinorphrenie, 5HT What TCA medication should absolutely not be used in combination with any other MAOI? correct answer: chlomipramine Please know what is the most potent property of trazodone by what neurotransmitter? correct answer: SEDATION; 5H2A Patient prescribed Clomipramine suddenly stops taking medication. What side effects could be shown? correct answer: Cardiovascular, coma, seizure, death What neurotransmitters are effected by tricyclic antidepressan