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CPJE Top 400 Drugs training wheel ver.| 411 QUESTIONS WITH COMPLETE SOLUTIONS $15.49
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CPJE Top 400 Drugs training wheel ver.| 411 QUESTIONS WITH COMPLETE SOLUTIONS
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Tylenol (I,D,Overdose) Acetaminophen I: fever/pain D: 325-650mg, max < 4000mg/day from all sources *OD = liver damage, use NAC for antidote Ofirmev (IV) (I,D,Overdose) Acetaminophen I: fever/pain D: < 4000mg/day from all sources *Can treat more severe pain *OD = liver damage, use NA...

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  • March 20, 2023
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CPJE Top 400 Drugs training wheel ver.| 411 QUESTIONS
WITH COMPLETE SOLUTIONS
Tylenol (I,D,Overdose)
Acetaminophen
I: fever/pain
D: 325-650mg, max < 4000mg/day from all sources
*OD = liver damage, use NAC for antidote
Ofirmev (IV) (I,D,Overdose)
Acetaminophen
I: fever/pain
D: < 4000mg/day from all sources
*Can treat more severe pain
*OD = liver damage, use NAC for antidote
NAC (I)
N-acetylcysteine
I: APAP overdose
Bayer (I,D,CI,OD,BBW)
Aspirin
I: fever/pain/inflammation
D: 81-325mg qd
CI: pregnancy (esp 3rd trimester), OD = tinnitis
*BBW: COX-1 selectivity NSAID = GI bleed
Motrin, Advil (I,D,BBW) Ibuprofen
I: fever/pain/inflammation
Dose
-OTC: 200-400mg q 4-6 hrs
-Rx: 600-800 mg tid, max 3200mg/d
*BBW: COX-1 selectivity NSAID = GI bleed
Naprosyn (I,D,BBW)
Naproxen, Aleve
I: fever/pain/inflammation
D:
-OTC: 220mg qd
-Rx: 250-550mg bid
*Higher GI side effects
*BBW: COX-1 selectivity NSAID = GI bleed
Daypro (I,BBW)
Oxaprozin
I: fever/pain/inflammation
*Similar caution to piroxicam: high risk for GI tox and severe SJS
*BBW: COX-1 selectivity NSAID = GI bleed
Voltaren (I,D)
Diclofenac (gel)
I: pain/inflammation
Dose: AAA 2-4g QID
Toradol (I,D -IV/PO/Max-,BBW)
Ketorolac
I: analgesia D:
-IV/IM 30mg x 1, or 30mg QID (max 120mg/d)
-PO: 20mg once after IV or IM, then 10mg q4-6hr (max: 40mg/d)
*Max = 5 days of treatment
*Most GI toxic w/ piroxicam
*BBW: COX-1 selectivity NSAID = GI bleed
Indocin (I,D,BBW)
Indomethacin
-I: fever/pain/inflammation, gout
-D: 25-50mg IR, 75mg BID CR
*High risk for CNS SE and GI toxicity
*BBW: COX-1 selectivity NSAID = GI bleed
Clinoril (BBW)
Sulindac
*less common NSAID that may be better w/ reduced renal function
*BBW: COX-1 selectivity NSAID = GI bleed
Relafen (I,D)
Nabumetone
I: fever/pain/inflammation
D: 1000-200mg qd or bid
Feldene (I,D,BBW)
Piroxicam
I: fever/pain/inflammation
D: 10-20mg qd
*High risk for GI tox and severe SJS *Most GI toxic w/ ketorolac
*BBW: COX-1 selectivity NSAID = GI bleed
Mobic (I,D, selectivity)
Meloxicam
I: fever/pain/inflammation
D: 7.5-15mg po (Max: 15mg/d)
*COX-2 selectivity NSAID: CV event (MI, stroke)
Celebrex (I,D,selectivity)
Celecoxib
I: fever/pain/inflammation
D: 200mg qd or BID
*lowest GI bleed risk but highest CV risk
*COX-2 selectivity NSAID: CV event (MI, stroke)
Humira (I,D,BBW)
Adalimumab
I: arthritis, psoriasis, Crohn's, UC, etc
D: 40mg SC every other week
*BBW: fatal infections, malignancy, TB
Remicade (I,D,SE,BBW)
Infliximab
I: arthritis, psoriasis, Crohn's, UC, etc
D: 3 mg/kg IV on weeks 0, 2 and 6, then q8w
*Delayed hypersensitivity reactions
*BBW: fatal infections, malignancy, TB
Enbrel (I,D,BBW)

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