NRNP 6566 WK1-5 Midterm question with complete solution graded A+

Describe cytochrome p450 system - Cytochrome p450 system is a series of enzymes used to metabolize medications Inhibitors - block metabolic activity from one or more CYP450 enzymes Inducers - increase CYP450 enzyme activity by increasing enzyme synthesis Describe effect on low and high albumin levels on active drug levels especially for drugs that are highly protein bound - Albumin is the plasma protein with the greatest capacity for binding drugs. Binding plasma proteins affect drug distribution into tissues, because only drug that is not bound is available to penetrate tissues, bind to receptors, and exert activity. As free drug leaves the blood stream, more bound drug is released from binding sites. Low albumin levels - malnutrition, chronic illness Highly protein bound drugs can lead to - toxicity in patients with low albumin levels, example malnutrition or chronic illness. This is because there are fewer than the normal sites for the drug to bind Describe the ways the hepatic first pass effect- which is metabolism during first pass through the liver - Alternative routes include: suppository intravenous intramuscular inhalational aerosol transdermal sublingual These allow drugs to bypass the first-pass effect and be absorbed directly into systemic circulationBe able to calculate creatinine clearance using Cockgraft Gault equation: - Male = 140-age times weight in kilograms divided by serum creatinine times 72.