CPPS 304 PRO FINAL EXAM AND UPDATED VERIFIED ANSWERS 2024.

warfarin effect and monitoring Answer - - blood thinner, reduces clots. safety concerns around bleeding when warfarin levels too high - monitored using international normalized ratio via blood test factors that influence drug response Answer - - adherence - DDI's - body composition - gender - age - genetics single nucleotide polymorphisms Answer - variation in a DNA sequence occurring when a single nucleotide in a genome is altered important factor in why some patients experience harm from a drug and others do not pharmacogenetics Answer - the study of how genetic variation affects an individual's response to drugs can predict who will benefit/be harmed most from a given drug poor vs fast metabolizers effect on pharmacokinetics Answer - poor: low enzymes, drug accumulates fast: extra enzymes, drug depleted faster intermediate: drug still accumulates, but not as badly most common isozyme for polymorphisms Answer - CYP 2D6