WALDEN NURS 6630 PSYCHOPHARMACOLOGY EXAM WITH GUARANTEED CORRECT ANSWERS

Serotonin regulates - correct answer Mood, emotion, feeding, and reproductive behavior This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors - correct answer SSRIs First line therapy for MDD due to milder side effect profiles - correct answer SSRIs Six Common SSRIs - correct answer citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline, paroxetine Onset of therapeutic benefit from SSRIs - correct answer 4-6 weeks In addition to MDD, SSRIs also treat - correct answer Chronic Anxiety, PTSD, OCD, and eating disorders (bulimia) Five Common side effects of SSRIs include - correct answer Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH Severe side effect of SSRIs in children/adolescents under age 25 years old - correct answer suicidal ideation Life threatening adverse effect of SSRIs, especially when used in combination with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - correct answer Serotonin Syndrome Excess accumulation of serotonin resulting in overstimulation of the nervous system - correct answer Serotonin Syndrome Seven symptoms of Serotonin Syndrome - correct answer Flushing, hyperthermia, agitation, muscle rigidity, seizure, coma, HYPERreflexia The treatment for serotonin syndrome - correct answer Cyproheptadine (5-HT2 receptor antagonist) Cyproheptadine treats serotonin syndrome by - correct answer blocking 5-HT2 receptors (serotonin antagonist) When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include - correct answer Irritability, headaches, and insomnia Medicine specific side effect of citalopram - correct answer Prolonged QT interval (normal=0.4.-0.44 seconds) This SSRI is pregnancy category D due to associations with congenital heart defects - correct answer Paroxetine All SSRIs but paroxetine (D) are pregnancy category - correct answer C Three SSRIs that are inhibitors of Cytochrome P450 enzymes - correct answer fluoxetine, fluvoxamine, and paroxetine Five common SNRIs include - correct answer duloxetine, venlafaxine, desvenlafaxine, milnacipran, levomilnacipran This antidepressant class of medications works by binding to presynaptic SERT and NET to inhibit them from reuptake of serotonin and norepinephrine to increase their levels in the synaptic cleft - correct answer SNRIs In addition to MDD SNRIs treat - correct answer Anxiety and neuropathic pain (peripheral neuropathy) Medication specific indications of duloxetine: - correct answer urinary incontinence and Fibromyalgia Medication specific indications of venlafaxine: - correct answer social anxiety, panic disorders, PTSD, OCD, postmenopausal hot flashes Six common side effects of SNRIs include: - correct answer Insomnia, nausea, sexual dysfunction,