Exam (elaborations)
ASCP BLOOD BANK Questions with Correct Answer
- Course
- Institution
ASCP BLOOD BANK Questions with Correct Answer
[Show more]
Content preview
ASCP BLOOD BANK Questions with CorrectAnswers
serum contains this ab more than others Correct Answer-IgG
this ab is majorly found in body secretions Correct Answer-IgA
the ___ portion of an antibody is responsible for placental transfer of
IgG, is responsible for complement fixation and causes problems for the
baby Correct Answer-Fc portion of IgG
these antibodies activate the classical complement pathway Correct
Answer-IgG, IgM
___ ab reacts at 37C (body temp) while _____ ab reacts at room temp
Correct Answer-IgG (body), IgM (room)
IgM Correct Answer--can activate classical pathway of complement
system
-only one molecule is necessary to activate complement
-results in hemolysis of RBCs and intravascular destruction (IV
hemolysis)
-ABO abs are typically IgM and can cause rapid hemolysis if an
incompatible unit is transfused
-expected in plasma, important in reverse typing
-these abs are IgM: Lewis, Ii, P, MNS
,-react best at ambient/room temp (22-24C)
-can interfere with detection of clinically significant IgG abs by masking
reactivity
-exist in moth monomeric and polymeric forms as pentamers containing
a J chain. These large molecules cause visible agglutination reactions of
ag-positive RBCs in saline
-pentameric form can be dissociated through cleavage of its covalent
bonds at the J chain using sulfhydral reducing agents
-IgM is removed by treatment with 2-ME and DTT
IgA Correct Answer--exists in both monomer and polymer form as
dimers or trimers composed of identical monomers
-about 30% of anti-A and anti-B antibodies are IgA class
-present in large amounts in body secretions
IgE Correct Answer--found only in monomeric form in trace
concentrations in serum. Important in allergic reactions
-Fc portion of IgE molecule attaches to basophils and mast cells, which
facilitates histamine release
-not known for hemolytic transfusion reactions
intravascular hemolysis occurs with ___ antibodies Correct Answer--
alloantibodies if complement is triggered
alloantibodies Correct Answer--antibodies produced after exposure to
genetically different, non-self of the same species
,Paroxysmal cold hemoglobinuria occurs with ____ Correct Answer-
autoantibodies- autoimmune disorder under cold temperatures.
extravascular hemolysis Correct Answer--occurs in the liver/spleen
-occurs as a result of abs coating RBCs (either self or non-self)
-removed by mononuclar phagocyte system
-split products of complement activation can stimulate the
reticuloendothelial system (RES)
human leukocyte antigens (HLAs) are _____ Correct Answer-
glycoproteins
most clinically significant blood group antigens and immunogenicity
(chance of body making antibody against it) Correct Answer--D (Rh) -
50%
-K (Kell) - 5%
-c (Rh)-2.05
-E (Rh) -decreased from here
-k (kell)
-e (Rh)
-Fya (Duffy)
-C (Rh)
-Jka (Kidd)
-S (MNSs)
, -Jkb (Kidd)
-s (MNSs)
antibodies against this blood group antigen tends to fall below detection
limit of titer Correct Answer-Kidd (Jka)
** ask if patient has ever received a transfusion and from where!!
factors that influence Ag-Ab reactions Correct Answer--centrifugation
-Ag-Ab ratio
-pH
-temperature
IgM antibodies that typically react in the immediate spin phase Correct
Answer-A, B, H, I, P1, M, N, Le^a, Le^b
IgG antibodies that react after the antiglobulin phase (37C) Correct
Answer-D, C, E, c, e, K, Fy, Jk, S, s, Le^1, Le^b
Factors that influence agglutination reactions Correct Answer--22%
albumin
-LISS
-PeG
-proteolytic enzymes
-chemical reduction (DTT, B-2-ME)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller cracker. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
62890 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now
