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Medical Laboratory Science Review
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Medical Laboratory Science Review
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Medical Laboratory Science Review - Harr - BloodBank Questions with Correct Answers
What type of serological testing does the blood bank technologist
perform when determining the blood group of a patient?
A. Genotyping
B. Phenotyping
C. Both genotyping and phenotyping
D. Polymerase chain reaction Correct Answer-B Phenotyping, or the
physical expression of a genotype, is the type of testing routinely
performed in the blood bank. An individual, for example, may have the
AO genotype but phenotypes as group A.
If anti-K reacts 3+ with a donor cell with a genotype KK and 2+ with a
Kk cell, the antibody is demonstrating:
A. Dosage
B. Linkage disequilibrium
C. Homozygosity
,D. Heterozygosity Correct Answer-A Dosage is defined as an antibody
reacting stronger with homozygous cells (such as KK) than with
heterozygous cells (such as Kk). In addition to Kell, dosage effect is
seen commonly with antigens M, N, S, s, Fya, Fyb, Jka, Jkb, and the
antigens of the Rh system.
Carla expresses the blood group antigens Fya, Fyb, and Xga. James
shows expressions of none of these antigens. What factor(s) may
account for the absence of these antigens in James?
A. Gender
B. Race
C. Gender and race
D. Medication Correct Answer-C The frequency of Duffy antigens Fya
and Fyb varies with race. The Fy(a−b−) phenotype occurs in almost 70%
of African Americans and is very rare in whites. The Xga antigen is X-
linked and, therefore, expressed more frequently in women (who may
inherit the antigen from either parent) than in men.
Which of the following statements is true?
A. An individual with the BO genotype is homozygous for B antigen
,B. An individual with the BB genotype is homozygous for B antigen
C. An individual with the OO genotype is heterozygous for O antigen
D. An individual with the AB phenotype is homozygous for A and B
antigens Correct Answer-B An individual having the BB genotype has
inherited the B gene from both parents and, therefore, is homozygous for
B antigen.
Which genotype is heterozygous for C?
A. DCe\dce
B. DCE\DCE
C. Dce\dce
D. DCE\dCe Correct Answer-A The genotype DCe\dce contains one C
and one c gene and is heterozygous for C and c antigens.
Which genotype(s) will give rise to the Bombay phenotype?
A. HH only
, B. HH and Hh
C. Hh and hh
D. hh only Correct Answer-D The Bombay phenotype will be expressed
only when no H substance is present. The Oh type is expressed by the
genotype hh. Bombays produce naturally occurring anti-H, and their
serum agglutinates group O red cells in addition to red cells from groups
A, B, and AB persons.
Meiosis in cell division is limited to the ova and sperm producing four
gametes containing what complement of DNA?
A. 1N
B. 2N
C. 3N
D. 4N Correct Answer-A Meiosis involves two nuclear divisions in
succession resulting in four gametocytes each containing half the
number of chromosomes found in somatic cells or 1N.
A cell that is not actively dividing is said to be in:
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